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IL-17R / IL-17RA (CD217) 항체, 토끼 다클론 항체, Antigen Affinity Purified

데이터시트리뷰프로토콜
제품 설명: Active  
발현 숙주: Human Cells  
  • Slide 1
10895-H08H-50
10895-H08H-100
50 µg 
100 µg 
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제품 설명: Active  
발현 숙주: Human Cells  
  • Slide 1
10895-H03H-200
10895-H03H-100
200 µg 
100 µg 
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발현 숙주: Human Cells  
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50328-M02H-200
50328-M02H-100
200 µg 
100 µg 
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제품 설명: Active  
발현 숙주: Human Cells  
  • Slide 1
50328-M08H-50
50328-M08H-100
50 µg 
100 µg 
Add to Cart
발현 숙주: Human Cells  
  • Slide 1
80190-R02H-200
80190-R02H-100
200 µg 
100 µg 
Add to Cart
발현 숙주: Human Cells  
  • Slide 1
80190-R08H-200
80190-R08H-100
200 µg 
100 µg 
Add to Cart

IL17RA/IL-17RA/CD217 ELISA Pair Set

검출 한계: 31.25 pg/ml
SEK10895-5
SEK10895-15
5 Plates 
15 Plates 
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IL17RA/IL-17RA/CD217 antibody 연구배경

Interleukin-17 receptor (IL-17R), also known as Interleukin-17 receptor A (IL-17RA) and CD217 antigen (CD217), is a cytokine receptor which binds interleukin 17. IL-17R/IL-17RA (CD217) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. IL-17R/IL-17RA (CD217) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor IL-17RA play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Defects in IL-17R/IL-17RA (CD217) are the cause of familial candidiasis type 5 (CANDF5). CANDF5 is a rare disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans.

 IL17RA/IL-17RA/CD217 antibody 참고자료
  • Gaffen SL. (2009) Structure and signalling in the IL-17 receptor family. Nat Rev Immunol. 9 (8): 556-67.
  • Johansen C, et al.. (2009) Characterization of the interleukin-17 isoforms and receptors in lesional psoriatic skin. Br J Dermatol. 160 (2): 319-24.
  • Yao Z, et al.. (1997) Molecular characterization of the human interleukin (IL)-17 receptor. Cytokine 9 (11): 794-800.
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