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IL18RAP 항체, 토끼 다클론 항체, Antigen Affinity Purified

데이터시트리뷰프로토콜
발현 숙주: Human Cells  
  • Slide 1
10176-H02H-200
10176-H02H-100
200 µg 
100 µg 
Add to Cart
제품 설명: Active  
발현 숙주: Human Cells  
  • Slide 1
10176-H08H-20
10176-H08H-100
20 µg 
100 µg 
Add to Cart
발현 숙주: Baculovirus-Insect cells  
  • Slide 1
50845-M08B-50
50845-M08B-100
50 µg 
100 µg 
Add to Cart
발현 숙주: Human Cells  
  • Slide 1
90122-C08H-200
90122-C08H-100
200 µg 
100 µg 
Add to Cart
발현 숙주: Human Cells  
  • Slide 1
90122-C02H-200
90122-C02H-100
200 µg 
100 µg 
Add to Cart

IL18RAP ELISA Pair Set

검출 한계:
SEK10176-5
SEK10176-15
5 Plates 
15 Plates 
Add to Cart

IL18RAP AntibodyRelated Products

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IL18RAP antibody 연구배경

Interleukin 18 receptor accessory protein, also known as IL18RAP and CDw218b (cluster of differentiation w218b), is an accessory subunit of the heterodimeric receptor for IL18. This protein enhances the IL18 binding activity of IL18R1 (IL1RRP), a ligand binding subunit of IL18 receptor. The coexpression of IL18R1 and this protein is required for the activation of NF-kappaB and MAPK8 (JNK) in response to IL18. IL18RAP is required for the high affinity binding of interleukin 18 (IL-18) to its receptor complex. IL18RAP together with IL18R1 mediates IL-18-dependent activation of NF-kappa-B and JNK. Two putative isoforms of IL18RAP were detected and the ratios and total levels of these isoforms may contribute to the aetiology of coeliac disease. IL18R1 and IL18RAP polymorphisms have been found associated with diseases such as schizophrenia, HSV1 seropositivity and atopic asthma. Analysis of IL18R1 and IL18RAP SNPs in 5 European prospective cohorts suggests that the variability of these genes are unlikely to contribute to modulate the risk of CVD in European populations.

휴먼 IL18RAP antibody 참고자료
  • Zhernakova A, et al.. (2008) Genetic analysis of innate immunity in Crohn's disease and ulcerative colitis identifies two susceptibility loci harboring CARD9 and IL18RAP. Am J Hum Genet. 82(5): 1202-10.
  • Grisoni ML, et al.. (2009) Lack of association between polymorphisms of the IL18R1 and IL18RAP genes and cardiovascular risk: the MORGAM Project. BMC Med Genet. 10: 44.
  • Koskinen LL, et al.. (2009) Association study of the IL18RAP locus in three European populations with coeliac disease. Hum Mol Genet. 18(6): 1148-55.
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