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APOA1 / ApoAI 항체, 토끼 다클론항체

데이터시트리뷰프로토콜
발현 숙주: E. coli  
  • Slide 1
10686-H07E-50
10686-H07E-100
50 µg 
100 µg 
Add to Cart
제품 설명: Active  
발현 숙주: Human Cells  
  • Slide 1
10686-H02H-50
10686-H02H-100
50 µg 
100 µg 
Add to Cart
발현 숙주: Human Cells  
  • Slide 1
50918-M08H-200
50918-M08H-100
200 µg 
100 µg 
Add to Cart
제품 설명: Active  
발현 숙주: Human Cells  
  • Slide 1
50918-M02H-200
50918-M02H-100
200 µg 
100 µg 
Add to Cart

MP200887 

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Apolipoprotein A-I/ApoA1 antibody 연구배경

Apolipoprotein A1 (APOA1) is a member of the apolipoprotein family whose members are proteins bind with lipids and form lipoproteins to translate these oil-soluble lipids such as fat and cholesterol through lymphatic and circulatory system. APOA1 is the main component of high density lipoprotein (HDL) in plasma and is involved in the esterification of cholesterol as a cofactor of lecithin-cholesterol acyltransferase (LCAT) which is responsible for the formation of most plasma cholesteryl esters, and thus play a major role in cholesterol efflux from peripheral cells. As a major component of the HDL complex, APOA1 helps to clear cholesterol from arteries. APOA1 is also characterized as a prostacyclin stabilizing factor, and thus may have an anticlotting effect. Defects in encoding gene may result in HDL deficiencies, including Tangier disease, and with systemic non-neuropathic amyloidosis. Men carrying a mutation may develop premature coronary artery disease.

휴먼 Apolipoprotein A-I/ApoA1 antibody 참고자료
  • Toptas B, et al. (2011) Comparison of lipid profiles with APOA1 MspI polymorphism in obese children with hyperlipidemia. In Vivo. 25(3): 425-30.
  • Haase CL, et al. (2011) Mutation in APOA1 predicts increased risk of ischaemic heart disease and total mortality without low HDL cholesterol levels. J Intern Med. 270(2): 136-46.
  • Wu Z, et al. (2011) The low resolution structure of ApoA1 in spherical high density lipoprotein revealed small angle neutron scattering. J Biol Chem. 286(14): 12495-508.
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