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EpCAM / TROP-1 / TACSTD1 항체, 생쥐 단클론항체

데이터시트리뷰프로토콜
발현 숙주: Human Cells  
  • Slide 1
10694-H08H-50
10694-H08H-100
50 µg 
100 µg 
Add to Cart
발현 숙주: Human Cells  
  • Slide 1
10694-H02H-50
10694-H02H-100
50 µg 
100 µg 
Add to Cart
발현 숙주: Human Cells  
  • Slide 1
50591-M08H-50
50591-M08H-100
50 µg 
100 µg 
Add to Cart
발현 숙주: Human Cells  
  • Slide 1
80306-R08H-50
80306-R08H-100
50 µg 
100 µg 
Add to Cart
발현 숙주: Human Cells  
  • Slide 1
80306-R02H-50
80306-R02H-100
50 µg 
100 µg 
Add to Cart
발현 숙주: Human Cells  
  • Slide 1
90299-C02H-50
90299-C02H-100
50 µg 
100 µg 
Add to Cart
발현 숙주: Human Cells  
  • Slide 1
90299-CCCH-50
90299-CCCH-100
50 µg 
100 µg 
Add to Cart
발현 숙주: Human Cells  
  • Slide 1
90299-C08H-50
90299-C08H-100
50 µg 
100 µg 
Add to Cart

EpCAM/TROP-1/TACSTD1 ELISA Pair Set

검출 한계:
SEK50591-5
SEK50591-15
5 Plates 
15 Plates 
Add to Cart
검출 한계: 46.8 pg/ml
SEK10694-5
SEK10694-15
5 Plates 
15 Plates 
Add to Cart

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EpCAM/TROP-1/TACSTD1 antibody 연구배경

Epithelial Cell Adhesion Molecule (EpCAM), also known as GA733-2 antigen, is a type â… transmembrane glycoprotein composed of an extracellular domain with two EGF-Like repeats and a cystenin-rich region, a transmembrane domain and a cytoplasmic domain. It modulates cell adhesion and proliferation. Its overexpression has been detected in many epithelial tumours and has been associated with high stage, high grade and a worse survival in some tumour types. EpCAM has been shown to function as a calcium-independent homophilic cell adhesion molecule that does not exhibit any obvious relationship to the four known cell adhesion molecule superfamilies. However, recent insights have revealed that EpCAM participates in not only cell adhesion, but also in proliferation, migration and differentiation of cells. In addition, recent study revealed that EpCAM is the Wnt-beta-catenin signaling target gene and may be used to facilitate prognosis. It has oncogenic potential and is activated by release of its intracellular domain, which can signal into the cell nucleus by engagement of elements of the wnt pathway.

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

휴먼 EpCAM/TROP-1/TACSTD1 antibody 참고자료
  • Brunner A, et al. (2008) EpCAM is predominantly expressed in high grade and advanced stage urothelial carcinoma of the bladder. J Clin Pathol. 61(3):307-10.
  • Trzpis M, et al. (2008) EpCAM in morphogenesis. Front Biosci. 13: 5050-5.
  • Munz M, et al. (2009) The emerging role of EpCAM in cancer and stem cell signaling. Cancer Res. 69(14): 5627-9.
  • Carpenter G, et al. (2009) EpCAM: another surface-to-nucleus missile. Cancer Cell. 15(3): 165-6.
  • 주의 : 모든 제품은 "연구 목적만을 위한 것이며 진단이나 치료에 사용하도록 의도되지 않았습니다".