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BAMBI / NMA 항체, 생쥐 단클론항체

데이터시트리뷰프로토콜
발현 숙주: Human Cells  
  • Slide 1
10890-H08H-50
10890-H08H-20
50 µg 
20 µg 
Add to Cart
발현 숙주: Human Cells  
  • Slide 1
50895-M02H-50
50895-M02H-20
50 µg 
20 µg 
Add to Cart
발현 숙주: Human Cells  
  • Slide 1
50895-M08H-50
50895-M08H-20
50 µg 
20 µg 
Add to Cart

BAMBI/NMA ELISA Pair Set

검출 한계: 9.375 pg/ml
SEK10890-5
SEK10890-15
5 Plates 
15 Plates 
Add to Cart

BAMBI/NMA AntibodyRelated Products

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BAMBI/NMA antibody 연구배경

BMP and activin membrane-bound inhibitor (BAMBI) is a transmembrane glycoprotein that is a pseudoreceptor of type 1 receptors. BAMBI structurally lacks intracellular serine/ threonine kinase domain but with an extracellular domain and a short cytoplasmic region that share sequence similarities with type 1 receptors, whose members have functions in signal transduction in various developing and pathological processes. BAMBI competes with the type 1 receptor, a receptor of the transforming growth factor-beta (TGF-beta), through functioning as negative regulators of TGF-beta by limiting the signaling range of the TGF-beta family during early embryogenesis. The expression of BAMBI can be induced by accumulated beta-catenin and BMP. The expression level of BAMBI was found aberrantly elevated in most colorectal and hepatocellular carcinomas relative to the corresponding non-cancerous tissues. It suggestes that beta-catenin and TGF-beta interfere growth arrest by inducing the expression of BAMBI, and this may contribute to colorectal and hepatocellular tumorigenesis.

휴먼 BAMBI/NMA antibody 참고자료
  • Sekiya T, et al. (2003) Identification of BMP and Activin Membrane-bound Inhibitor (BAMBI), an Inhibitor of Transforming Growth Factor- Signaling, as a Target of the -Catenin Pathway in Colorectal Tumor Cells. The Journal of Biological Chemistry. 279:6840-6.
  • Shi YG, et al. (2003) Mechanisms of TGF- Signaling from Cell Membrane to the Nucleus. Cell. 113(6): 685-700.
  • Wanninger J, et al. (2011) Adiponectin induces the transforming growth factor decoy receptor BAMBI in human hepatocytes. FEBS Lett. 585(9):1338-44.
  • 주의 : 모든 제품은 "연구 목적만을 위한 것이며 진단이나 치료에 사용하도록 의도되지 않았습니다".