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휴먼 Vimentin / VIM 단백질 (His 태그)

데이터시트리뷰프로토콜
반응성: Human  
신청: IHC-P  
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100254-T08-50
100254-T08-200
100254-T08-100
50 µg 
200 µg 
100 µg 
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반응성: Human  
신청: WB  IHC-P  
  • Slide 1
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100254-T40-50
100254-T40-200
100254-T40-100
50 µg 
200 µg 
100 µg 
Add to Cart
반응성: Human  
신청: IHC-P  
  • Slide 1
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100254-R211-50
100254-R211-100
50 µg 
100 µg 
Add to Cart

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Vimentin protein 연구배경

Vimentin is a type III intermediate filament (IF) protein found in various non-epithelial cells, especially mesenchymal cells. A vimentin monomer, has a central α-helical domain and carboxyl (tail) domains. Two monomers compose the basic subunit of vimentin assembly. Vimentin is crucial for supporting and anchoring the position of the organelles in the cytosol. Vimentin provided cells with a resilience absent from the microtubule or actin filament networks, when under mechanical stress in vivo. Therefore, in general, it is accepted that vimentin is the cytoskeletal component responsible for maintaining cell integrity. Vimentin is also responsible for stabilizing cytoskeletal interactions. It is found that vimentin control the transport of low-density lipoprotein. It has been used as a sarcoma tumor marker to identify mesenchyme.

휴먼 Vimentin protein 참고자료
  • Russell RL, et al. (2001) Uridine phosphorylase association with vimentin. Intracellular distribution and localization. J Biol Chem. 276(16):13302-7.
  • Moinova, et al. (2012) Aberrant Vimentin Methylation is Characteristic of Upper GI Pathologies. Cancer Epidemiology Biomarkers Prev. 21(4):594-600.
  • Leader M, et al. (1987) Vimentin: an evaluation of its role as a tumour marker. Histopathology. 11(1):63-72.
  • 주의 : 모든 제품은 "연구 목적만을 위한 것이며 진단이나 치료에 사용하도록 의도되지 않았습니다".