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쥐 PD1/PDCD1/CD279 Gene ORF cDNA clone expression plasmid

데이터시트리뷰프로토콜
제품 설명: Active  
발현 숙주: Human Cells  
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10377-H03H-50
10377-H03H-100
50 µg 
100 µg 
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제품 설명: Active  
발현 숙주: Human Cells  
  • Slide 1
10377-H08H-50
10377-H08H-100
50 µg 
100 µg 
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발현 숙주: Human Cells  
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50124-M08H-200
50124-M08H-100
200 µg 
100 µg 
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제품 설명: Active  
발현 숙주: Human Cells  
  • Slide 1
50124-M03H-200
50124-M03H-100
200 µg 
100 µg 
Add to Cart
발현 숙주: Human Cells  
  • Slide 1
80448-R08H-200
80448-R08H-100
200 µg 
100 µg 
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발현 숙주: Human Cells  
  • Slide 1
80448-R02H-200
80448-R02H-100
200 µg 
100 µg 
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발현 숙주: Human Cells  
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90311-C02H-50
90311-C02H-100
50 µg 
100 µg 
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발현 숙주: Human Cells  
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70109-D08H-200
70109-D08H-100
200 µg 
100 µg 
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제품 설명:   
발현 숙주: Human Cells  
  • Slide 1
70109-D02H-200
70109-D02H-100
200 µg 
100 µg 
Add to Cart
발현 숙주: Human Cells  
  • Slide 1
90305-K02H-50
90305-K02H-100
50 µg 
100 µg 
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발현 숙주: Human Cells  
  • Slide 1
90305-K08H-50
90305-K08H-100
50 µg 
100 µg 
Add to Cart
반응성: Human  
신청: ELISA  
    10377-MF05-50
    10377-MF05-100
    50 µg 
    100 µg 
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    반응성: Human  
    신청: 
    • Slide 1
    • Slide 1
    • Slide 1
    10377-HN94-500
    10377-HN94-200
    500 µg 
    200 µg 
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    반응성: Human  
    신청: ELISA  
      10377-RP03-400
      10377-RP03-200
      10377-RP03-100
      400 µg 
      200 µg 
      100 µg 
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      반응성: Human  
      신청: B/N  
        10377-mhT28-500
        10377-mhT28-200
        500 µg 
        200 µg 
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        반응성: Human  
        신청: ELISA  
          10377-RP04-50
          10377-RP04-200
          10377-RP04-100
          50 µg 
          200 µg 
          100 µg 
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          반응성: Human  
          신청: 
            10377-MM03-50
            10377-MM03-200
            10377-MM03-100
            50 µg 
            200 µg 
            100 µg 
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            반응성: Human  
            신청: ELISA  
              10377-MM07-50
              10377-MM07-200
              10377-MM07-100
              10377-MM07-1
              50 µg 
              200 µg 
              100 µg 
              1 mg 
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              반응성: Human  
              신청: ELISA  IHC-P  
              • Slide 1
              • Slide 1
              • Slide 1
              10377-MF07-50
              10377-MF07-200
              10377-MF07-100
              50 µg 
              200 µg 
              100 µg 
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              반응성: Human  
              신청: ELISA  IHC-P  
              • Slide 1
              • Slide 1
              • Slide 1
              10377-RD67-50
              10377-RD67-100
              50 µg 
              100 µg 
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              반응성: Human  
              신청: B/N  
              • Slide 1
              10377-HF06-500
              10377-HF06-200
              500 µg 
              200 µg 
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              반응성: Human  
              신청: ELISA  WB  
              • Slide 1
              10377-T48-50
              10377-T48-200
              10377-T48-100
              50 µg 
              200 µg 
              100 µg 
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              반응성: Human  
              신청: ELISA  
                10377-R002-50
                10377-R002-100
                50 µg 
                100 µg 
                Add to Cart
                반응성: Mouse  
                신청: ELISA  
                  50124-R010-50
                  50124-R010-100
                  50 µg 
                  100 µg 
                  Add to Cart
                  반응성: Mouse  
                  신청: ELISA  
                    50124-T16-50
                    50124-T16-100
                    50 µg 
                    100 µg 
                    Add to Cart
                    반응성: Mouse  
                    신청: ELISA  
                      50124-RP01-400
                      50124-RP01-200
                      50124-RP01-100
                      400 µg 
                      200 µg 
                      100 µg 
                      Add to Cart
                      반응성: Mouse  
                      신청: ELISA  IHC-P  
                      • Slide 1
                      50124-RP02-50
                      50124-RP02-100
                      50 µg 
                      100 µg 
                      Add to Cart
                      반응성: Canine  
                      신청: ELISA  
                        70109-T16-50
                        70109-T16-200
                        70109-T16-100
                        50 µg 
                        200 µg 
                        100 µg 
                        Add to Cart
                        반응성: Canine  
                        신청: ELISA  
                          70109-RP01-400
                          70109-RP01-200
                          70109-RP01-100
                          400 µg 
                          200 µg 
                          100 µg 
                          Add to Cart
                          반응성: Canine  
                          신청: ELISA  
                            70109-R039-50
                            70109-R039-100
                            50 µg 
                            100 µg 
                            Add to Cart

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                            PD1/PDCD1/CD279 cdna-clone 연구배경

                            Programmed cell death 1, also known as PDCD1, is a type I transmembrane glycoprotein, and is an immunoreceptor belonging to the CD28/CTLA-4 family negatively regulates antigen receptor signaling by recruiting protein tyrosine phosphatase, SHP-2 upon interacting with either of two ligands, PD-L1 or PD-L2. PD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition, coligation of PD1 inhibits BCR-mediating signal by dephosphorylating key signal transducer. PD1 has been suggested to be involved in lymphocyte clonal selection and peripheral tolerance, and thus contributes to the prevention of autoimmune diseases. Furthermore, PD1 is shown to be a regulator of virus-specific CD8+ T cell survival in HIV infection. As a cell surface molecule, PDCD1 regulates the adaptive immune response. Engagement of PD-1 by its ligands PD-L1 or PD-L2 transduces a signal that inhibits T-cell proliferation, cytokine production, and cytolytic function.

                            Immune Checkpoint
                            Immune Checkpoint Blockade: Blocking Antibodies   Immune Checkpoint Blockade: PD1 / PDCD1 / CD279 Blocking Antibodies
                            Immune Checkpoint Detection: Antibodies   Immune Checkpoint Detection: ELISA Antibodies   Immune Checkpoint Detection: IHC Antibodies   Immune Checkpoint Detection: WB Antibodies
                            Immune Checkpoint Proteins   PD1 / PDCD1 / CD279 Immune Checkpoint Proteins
                            PD1 / PDCD1 / CD279 Immune Checkpoint   PD1 / PDCD1 / CD279 Immune Checkpoint Antibodies
                            Immune Checkpoint Targets   Co-inhibitory Immune Checkpoint Targets

                            Immunotherapy   Cancer Immunotherapy   Targeted Therapy

                             PD1/PDCD1/CD279 cdna-clone 참고자료
                          • James ES, et al. (2005) PDCD1: a tissue-specific susceptibility locus for inherited inflammatory disorders. Genes Immun. 6(5): 430-7.
                          • Okazaki T, et al. (2007) PD-1 and PD-1 ligands: from discovery to clinical application. Int Immunol. 19(7): 813-24.
                          • del Rio ML, et al. (2008) PD-1/PD-L1, PD-1/PD-L2, and other co-inhibitory signaling pathways in transplantation. Transpl Int. 21(11): 1015-28.
                          • Riley JL.(2009) PD-1 signaling in primary T cells. Immunol Rev. 229(1): 114-25.
                          • 주의 : 모든 제품은 "연구 목적만을 위한 것이며 진단이나 치료에 사용하도록 의도되지 않았습니다".