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쥐 PD-L1/B7-H1/CD274 Gene ORF cDNA clone expression plasmid

데이터시트리뷰프로토콜
발현 숙주: Human Cells  
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10084-H05H-20
10084-H05H-100
20 µg 
100 µg 
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제품 설명: Active  
발현 숙주: Human Cells  
  • Slide 1
10084-H02H-200
10084-H02H-100
200 µg 
100 µg 
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제품 설명: Active  
발현 숙주: Human Cells  
  • Slide 1
10084-H08H-200
10084-H08H-100
200 µg 
100 µg 
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제품 설명: Active  
발현 숙주: Human Cells  
  • Slide 1
50010-M03H-200
50010-M03H-100
200 µg 
100 µg 
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제품 설명: Active  
발현 숙주: Human Cells  
  • Slide 1
50010-M08H-200
50010-M08H-100
200 µg 
100 µg 
Add to Cart
발현 숙주: Human Cells  
  • Slide 1
50010-M02H-200
50010-M02H-100
200 µg 
100 µg 
Add to Cart
발현 숙주: Human Cells  
  • Slide 1
80450-R02H-200
80450-R02H-100
200 µg 
100 µg 
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발현 숙주: Human Cells  
  • Slide 1
80450-R08H-200
80450-R08H-100
200 µg 
100 µg 
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발현 숙주: Human Cells  
  • Slide 1
90251-C02H-200
90251-C02H-100
200 µg 
100 µg 
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발현 숙주: Human Cells  
  • Slide 1
90251-C08H-200
90251-C08H-100
200 µg 
100 µg 
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발현 숙주: Human Cells  
  • Slide 1
70110-D02H-200
70110-D02H-100
200 µg 
100 µg 
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반응성: Human  
신청: ELISA  IHC-P  
  • Slide 1
10084-R015-50
10084-R015-100
50 µg 
100 µg 
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반응성: Human  
신청: B/N  
    10084-R639-500
    10084-R639-200
    500 µg 
    200 µg 
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    반응성: Human  
    신청: ELISA  
      10084-MM13-50
      10084-MM13-100
      50 µg 
      100 µg 
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      반응성: Human  
      신청: ELISA  
        10084-MM31-50
        10084-MM31-200
        10084-MM31-100
        50 µg 
        200 µg 
        100 µg 
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        반응성: Human  
        신청: IHC-P  
        • Slide 1
        • Slide 1
        • Slide 1
        10084-MB55-50
        10084-MB55-200
        10084-MB55-100
        50 µg 
        200 µg 
        100 µg 
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        반응성: Human  
        신청: ELISA  
          10084-RP02-50
          10084-RP02-100
          50 µg 
          100 µg 
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          반응성: Human  
          신청: ELISA  
            10084-T16-50
            10084-T16-100
            50 µg 
            100 µg 
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            반응성: Human  
            신청: ELISA  
              10084-R001-50
              10084-R001-100
              50 µg 
              100 µg 
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              반응성: Human  
              신청: ELISA  IHC-P  
              • Slide 1
              • Slide 1
              10084-T24-50
              10084-T24-200
              10084-T24-100
              50 µg 
              200 µg 
              100 µg 
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              반응성: Human  
              신청: ELISA  
                10084-MM02-50
                10084-MM02-200
                10084-MM02-100
                50 µg 
                200 µg 
                100 µg 
                Add to Cart
                반응성: Human  
                신청: ELISA  
                  10084-RP01-200
                  10084-RP01-100
                  200 µg 
                  100 µg 
                  Add to Cart
                  반응성: Mouse  
                  신청: ELISA  
                    50010-RP01-400
                    50010-RP01-200
                    50010-RP01-100
                    400 µg 
                    200 µg 
                    100 µg 
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                    반응성: Mouse  
                    신청: FCM  
                    • Slide 1
                    • Slide 1
                    50010-R485-P-25
                    50010-R485-P-100
                    25 Test 
                    100 Tests 
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                    반응성: Mouse  
                    신청: FCM  IF  ICC/IF  
                    • Slide 1
                    • Slide 1
                    50010-R485-50
                    50010-R485-100
                    50 µg 
                    100 µg 
                    Add to Cart
                    반응성: Mouse  
                    신청: ELISA  
                      50010-RP02-50
                      50010-RP02-200
                      50010-RP02-100
                      50 µg 
                      200 µg 
                      100 µg 
                      Add to Cart
                      반응성: Mouse  
                      신청: FCM  
                      • Slide 1
                      50010-R401-50
                      50010-R401-100
                      50 µg 
                      100 µg 
                      Add to Cart
                      반응성: Mouse  
                      신청: FCM  
                      • Slide 1
                      50010-R485-A-25
                      50010-R485-A-100
                      25 Test 
                      100 Tests 
                      Add to Cart

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                      PD-L1/B7-H1/CD274 cdna-clone 연구배경

                      Programmed death-1 ligand-1 (PD-L1, CD274, B7-H1) has been identified as the ligand for the immunoinhibitory receptor programmed death-1(PD1/PDCD1) and has been demonstrated to play a role in the regulation of immune responses and peripheral tolerance. PD-L1/B7-H1 is a member of the growing B7 family of immune molecules and this protein contains one V-like and one C-like Ig domain within the extracellular domain, and together with PD-L2, are two ligands for PD1 which belongs to the CD28/CTLA4 family expressed on activated lymphoid cells. By binding to PD1 on activated T-cells and B-cells, PD-L1 may inhibit ongoing T-cell responses by inducing apoptosis and arresting cell-cycle progression. Accordingly, it leads to growth of immunogenic tumor growth by increasing apoptosis of antigen specific T cells and may contribute to immune evasion by cancers. PD-L1 thus is regarded as promising therapeutic target for human autoimmune disease and malignant cancers.

                      Immune Checkpoint
                      Immune Checkpoint Blockade: Blocking Antibodies   Immune Checkpoint Blockade: PD-L1 / B7-H1 / CD274 Blocking Antibodies
                      Immune Checkpoint Detection: Antibodies   Immune Checkpoint Detection: ELISA Antibodies   Immune Checkpoint Detection: IHC Antibodies   Immune Checkpoint Detection: ICC Antibodies   Immune Checkpoint Detection: FCM Antibodies   Immune Checkpoint Detection: WB Antibodies
                      Immune Checkpoint Proteins   PD-L1 / B7-H1 / CD274 Immune Checkpoint Proteins
                      Immune Checkpoint Targets   Co-inhibitory Immune Checkpoint Targets

                      Immunotherapy   Cancer Immunotherapy   Targeted Therapy

                       PD-L1/B7-H1/CD274 cdna-clone 참고자료
                    • Iwai Y, et al. (2002) Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade. Proc Natl Acad Sci U S A. 99(19): 12293-7.
                    • Ghebeh H, et al. (2006) The B7-H1 (PD-L1) T lymphocyte-inhibitory molecule is expressed in breast cancer patients with infiltrating ductal carcinoma: correlation with important high-risk prognostic factors. Neoplasia. 8(3): 190-8.
                    • Salih HR, et al. (2006) The role of leukemia-derived B7-H1 (PD-L1) in tumor-T-cell interactions in humans. Exp Hematol. 34(7): 888-94.
                    • Wilcox RA, et al. (2009) B7-H1 (PD-L1, CD274) suppresses host immunity in T-cell lymphoproliferative disorders. Blood. 114(10): 2149-58.
                    • Ruggiero A, et al. (2009) Crystal structure of PD-L1, a ribosome inactivating protein from Phytolacca dioica L. leaves with the property to induce DNA cleavage. Biopolymers. 91(12): 1135-42.
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