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휴먼 TGFBR3 / Betaglycan Gene ORF cDNA clone expression plasmid, N-Flag 태그

데이터시트리뷰프로토콜
발현 숙주: Baculovirus-Insect Cells  
  • Slide 1
10778-H08B-50
10778-H08B-100
50 µg 
100 µg 
Add to Cart
발현 숙주: Human Cells  
  • Slide 1
50542-M08H-50
50542-M08H-100
50 µg 
100 µg 
Add to Cart
반응성: Mouse  
신청: ELISA  
    50542-R030-50
    50542-R030-100
    50 µg 
    100 µg 
    Add to Cart
    반응성: Mouse  
    신청: ELISA  
      50542-RP02-50
      50542-RP02-200
      50542-RP02-100
      50 µg 
      200 µg 
      100 µg 
      Add to Cart
      반응성: Mouse  
      신청: ELISA  
        50542-RP01-400
        50542-RP01-200
        50542-RP01-100
        400 µg 
        200 µg 
        100 µg 
        Add to Cart

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        TGFBR3 / Betaglycan cdna-clone 연구배경

        Betaglycan also known as transforming growth factor beta receptor III (TGFBR3), is a cell-surface chondroitin sulfate / heparan sulfate proteoglycan. TGFBR3 is a transforming growth factor (TGF)-beta type III receptor. This receptor is a membrane proteoglycan that often functions as a co-receptor with other TGF-beta receptor superfamily members. Ectodomain shedding produces soluble TGFBR3, which may inhibit TGFB signaling. Decreased expression of this receptor has been observed in various cancers. TGFBR3 is the TGF-β component most commonly downregulated among localized human prostate cancer studies. TGFBR3 knockdown led to focus formation and enhanced expression of CD133, a marker found on prostate cancer stem cells. TGFBR3 is an accessory receptor that binds to and modulates the activities of both transforming growth factor-beta (TGFβ) and inhibin, two members of the TGFβ superfamily of growth factors that regulate many aspects of reproductive biology. TGFBR3 is known to be expressed in adult testis and ovary, but little is known about this receptor during gonadogenesis.

        휴먼 TGFBR3 / Betaglycan cdna-clone 참고자료
      • Johnson DW, et al. (1996) Assignment of human transforming growth factor-beta type I and type III receptor genes (TGFBR1 and TGFBR3) to 9q33-q34 and 1p32-p33, respectively. Genomics. 28 (2): 356-7.
      • Rotzer D, et al. (2001) Type III TGF-beta receptor-independent signalling of TGF-beta2 via T betaRII-B, an alternatively spliced TGF- type II receptor. EMBO J. 20 (3): 480-90.
      • Gao J, et al. (1999) Expression of transforming growth factor-beta receptors types II and III within various cells in the rat periodontium. J Periodont Res. 34 (2): 113-22.
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