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쥐 IL22 / Interleukin 22 Gene ORF cDNA clone expression plasmid

데이터시트리뷰프로토콜
발현 숙주: E. coli  
  • Slide 1
13059-HNAE-20
13059-HNAE-10
20 µg 
10 µg 
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반응성: Human  
신청: ELISA  
    13059-RP01-400
    13059-RP01-200
    13059-RP01-100
    400 µg 
    200 µg 
    100 µg 
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    반응성: Human  
    신청: ELISA  
      13059-T16-50
      13059-T16-200
      13059-T16-100
      50 µg 
      200 µg 
      100 µg 
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      반응성: Human  
      신청: 
        13059-R034-50
        13059-R034-100
        50 µg 
        100 µg 
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        반응성: Mouse  
        신청: IHC-P  
        • Slide 1
        100326-T08-50
        100326-T08-200
        100326-T08-100
        50 µg 
        200 µg 
        100 µg 
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        IL22 / Interleukin 22 cdna-clone 연구배경

        IL22 is a member of a group of cytokines called the IL-10 family or IL-10 superfamily (including IL-19, IL-20, IL-24, and IL-26),  a class of potent mediators of cellular inflammatory responses. It shares use of IL-10R2 in cell signaling with other members of this family, IL-10, IL-26, IL-28A/B and IL-29. IL22 is produced by activated DC and T cells and initiates innate immune responses against bacterial pathogens especially in epithelial cells such as respiratory and gut epithelial cells. IL22 along with IL-17 is rapidly produced by splenic LTi-like cells and can be also produced by Th17 cells and likely plays a role in the coordinated response of both adaptive and innate immune systems.

        IL22 biological activity is initiated by binding to a cell-surface complex composed of IL-22R1 and IL-10R2 receptor chains and further regulated by interactions with a soluble binding protein, IL-22BP, which shares sequence similarity with an extracellular region of IL-22R1 (sIL-22R1). IL22 and IL-10 receptor chains play a role in cellular targeting and signal transduction to selectively initiate and regulate immune responses. IL22 can contribute to immune disease through the stimulation of inflammatory responses, S100s and defensins. IL22 also promotes hepatocyte survival in the liver and epithelial cells in the lung and gut similar to IL-10. In some contexts, the pro-inflammatory versus tissue-protective functions of IL22 are regulated by the often co-expressed cytokine IL-17A.

         IL22 / Interleukin 22 cdna-clone 참고자료
      • Pestka S. et al., 2004, Annu Rev Immunol. 22: 929-79.
      • Xie MH. et al., 2000, J Biol Chem. 275 (40): 31335-9.
      • Jones BC. et al., 2008, Structure. 16 (9): 1333-44.
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