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휴먼 IL-22BP/IL-22RA2 transcript variant 1 Gene ORF cDNA clone expression plasmid, N-Flag 태그

데이터시트리뷰프로토콜
발현 숙주: Human Cells  
  • Slide 1
11025-H03H-50
11025-H03H-20
50 µg 
20 µg 
Add to Cart
발현 숙주: Human Cells  
  • Slide 1
11025-H08H-50
11025-H08H-20
50 µg 
20 µg 
Add to Cart
반응성: Human  
신청: ELISA  
    11025-RP02-50
    11025-RP02-200
    11025-RP02-100
    50 µg 
    200 µg 
    100 µg 
    Add to Cart
    반응성: Human  
    신청: ELISA  
      11025-R028-50
      11025-R028-100
      50 µg 
      100 µg 
      Add to Cart
      반응성: Human  
      신청: ELISA  
        11025-RP01-400
        11025-RP01-200
        11025-RP01-100
        400 µg 
        200 µg 
        100 µg 
        Add to Cart
        반응성: Human  
        신청: ELISA  
          11025-MM05-50
          11025-MM05-200
          11025-MM05-100
          50 µg 
          200 µg 
          100 µg 
          Add to Cart

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          IL-22BP/IL-22RA2 cdna-clone 연구배경

          Interleukin-22 receptor subunit alpha-2 (IL-22RA2), also known as interleukin-22-binding protein (IL-22BP), is a subunit of the receptor for interleukin 22. IL-22BP belongs to the type I I cytokine receptor family and contains 3 fibronectin type-III domains. IL-22BP/IL-22RA2 is expressed in a range of tissues, including those in the digestive, female reproductive, and immune systems. It is expressed in placenta, spleen, breast, skin and lung. It is also detected in intestinal tract, testis, brain, heart and thymus. The dominant cell types expressing IL-22BP/IL-22RA2 were mononuclear cells and epithelium. IL-22BP/IL-22RA2 may play an important role as an IL-22 antagonist in the regulation of inflammatory responses. Interleukin-22 (IL-22) is a member of IL-10 family. It is produced by T cells and induces the production of acute-phase reactants. IL-22 plays important roles in immune response through activation of the STAT 3 signal transduction pathway. Two types of IL-22-binding receptor have been discovered, a membrane-bound receptor and a soluble receptor.

          휴먼 IL-22BP/IL-22RA2 cdna-clone 참고자료
        • Whittington HA, et al. (2004) Interleukin-22: a potential immunomodulatory molecule in the lung. Am J Respir Cell Mol Biol. 31(2): 220-6.
        • Dumoutier L, et al. (2001) Cloning and characterization of IL-22 binding protein, a natural antagonist of IL-10-related T cell-derived inducible factor/IL-22. J Immunol. 166(12): 7090-5.
        • Wei CC, et al. (2003) Cloning and characterization of mouse IL-22 binding protein. Genes Immun. 4(3): 204-11.
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