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휴먼 ASGR2 / ASGPR2 transcript variant 4 Gene ORF cDNA clone expression plasmid, C-Flag 태그

데이터시트리뷰프로토콜
제품 설명:   
발현 숙주: Human Cells  
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13908-H07H-50
13908-H07H-20
50 µg 
20 µg 
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반응성: Human  
신청: ELISA  IHC-P  
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13908-T24-50
13908-T24-100
50 µg 
100 µg 
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반응성: Human  
신청: ELISA  IHC-P  FCM  IF  ICC/IF  
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13908-R002-50
13908-R002-100
50 µg 
100 µg 
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반응성: Human  
신청: FCM  
  • Slide 1
13908-R002-P-25
13908-R002-P-100
25 Test 
100 Tests 
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ASGR2 / ASGPR2 cdna-clone 연구배경

ASGR2 is a subunit of the asialoglycoprotein receptor. Asialoglycoprotein receptor, also known as the Ashwell receptor, which is specific for desialylated (galactosyl-terminal) glycoproteins and is expressed exclusively in hepatic parenchymal cells. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. ASGR2 is a glycoprotein. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. ASGR2 is the less abundant minor subunit.

휴먼 ASGR2 / ASGPR2 cdna-clone 참고자료
  • Davila S, et al. (2010) New genetic associations detected in a host response study to hepatitis B vaccine. Genes Immun. 11(3):232-8.
  • Zhang X, et al. (2011) Asialoglycoprotein receptor interacts with the preS1 domain of hepatitis B virus in vivo and in vitro. Arch Virol. 156(4):637-45.
  • Guy CS, et al. (2011) Hepatocyte cytotoxicity is facilitated by asialoglycoprotein receptor. Hepatology. 54(3):1043-50.
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