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쥐 Fetuin-A Gene ORF cDNA clone expression plasmid

데이터시트리뷰프로토콜
제품 설명: Active  
발현 숙주: Human Cells  
  • Slide 1
10318-H08H-50
10318-H08H-100
50 µg 
100 µg 
Add to Cart
제품 설명: Active  
발현 숙주: Human Cells  
  • Slide 1
50093-M08H-50
50093-M08H-100
50 µg 
100 µg 
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반응성: Human  
신청: ELISA  IF  ICC/IF  
  • Slide 1
  • Slide 1
  • Slide 1
10318-R001-50
10318-R001-100
10318-R001-1
50 µg 
100 µg 
1 mg 
Add to Cart
반응성: Human  
신청: ELISA  
    10318-MM02-50
    10318-MM02-200
    10318-MM02-100
    10318-MM02-1
    50 µg 
    200 µg 
    100 µg 
    1 mg 
    Add to Cart
    반응성: Human  
    신청: ELISA  
      10318-T16-50
      10318-T16-200
      10318-T16-100
      50 µg 
      200 µg 
      100 µg 
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      반응성: Human  
      신청: ELISA  
        10318-RP01-400
        10318-RP01-200
        10318-RP01-100
        400 µg 
        200 µg 
        100 µg 
        Add to Cart
        반응성: Mouse  
        신청: 
          50093-R012-50
          50093-R012-100
          50093-R012-1
          50 µg 
          100 µg 
          1 mg 
          Add to Cart
          반응성: Mouse  
          신청: ELISA  
            50093-R002-50
            50093-R002-100
            50 µg 
            100 µg 
            Add to Cart
            반응성: Mouse  
            신청: ELISA  IHC-P  
            • Slide 1
            50093-RP02-50
            50093-RP02-200
            50093-RP02-100
            50 µg 
            200 µg 
            100 µg 
            Add to Cart
            반응성: Mouse  
            신청: IHC-P  
            • Slide 1
            50093-R022-50
            50093-R022-100
            50 µg 
            100 µg 
            Add to Cart
            반응성: Mouse  
            신청: ELISA  
              50093-RP01-400
              50093-RP01-200
              50093-RP01-100
              400 µg 
              200 µg 
              100 µg 
              Add to Cart

              Fetuin-A ELISA Pair Set

              검출 한계: 12.5 pg/ml
              SEKA10318-5
              SEKA10318-15
              5 Plates 
              15 Plates 
              Add to Cart
              검출 한계: 312.5 pg/ml
              SEK50093-5
              SEK50093-15
              5 Plates 
              15 Plates 
              Add to Cart

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              Fetuin-A cdna-clone 연구배경

              Fetuin-A, also known as Alpha-2-HS-Glycoprotein (AHSG), belongs to the Fetuin family, is a plasma binding protein, and is more abundant in fetal than adult blood. It is involved in several functions, such as endocytosis, brain development and the formation of bone tissue. Fetuins are carrier proteins like albumin. Fetuin-A forms soluble complexes with calcium and phosphate and thus is a carrier of otherwise insoluble calcium phosphate. Thus Fetuin-A is a potent inhibitor of pathological calcification. The circulating levels of fetuin-A, a well-described inhibitor of calcification, regulate the cell-dependent process of osteogenesis. The low circulating fetuin-A levels are associated with a greater prevalence and/or severity of Vascular calcification (VC) and increased risk for all-cause and cardiovascular mortality. However, high circulating fetuin-A levels appear to induce insulin resistance and, in non-dialyzed subjects with diabetic nephropathy, are directly related to VC burden. The emerging role of fetuin-A deficiency as a risk factor in dialysis patients was documented in cross-sectional studies demonstrating a significant correlation with all-cause and cardiovascular mortality. Additionally, Human fetuin-A is a negative acute phase protein involved in inflammatory diseases, thus being a potential physiological regulator of meprin activity. Fetuin-A is a broad-range protease inhibitor. Fetuin-A and cystatin C as endogenous proteolytic regulators of meprin activity broadens our understanding of the proteolytic network in plasma.

               Fetuin-A cdna-clone 참고자료
            • Mehrotra R. (2007) Emerging role for fetuin-A as contributor to morbidity and mortality in chronic kidney disease. Kidney Int. 72(2): 137-40.
            • Westenfeld R, et al. (2007) Vascular calcification and fetuin-A deficiency in chronic kidney disease. Trends Cardiovasc Med. 17(4): 124-8.
            • Heiss A, et al. (2008). Hierarchical role of fetuin-A and acidic serum proteins in the formation and stabilization of calcium phosphate particles. J Biol Chem. 283 (21): 14815-25.
            • Jahnen-Dechent W, et al. (2008). Mineral chaperones: a role for fetuin-A and osteopontin in the inhibition and regression of pathologic calcification. J Mol Med. 86 (4): 379-89.
            • Hedrich J, et al. (2010) Fetuin-A and cystatin C are endogenous inhibitors of human meprin metalloproteases. Biochemistry. 49(39): 8599-607.
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