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쥐 SerpinA1 Gene ORF cDNA clone expression plasmid

데이터시트리뷰프로토콜
제품 설명: Active  
발현 숙주: Human Cells  
  • Slide 1
10306-H08H-20
10306-H08H-10
20 µg 
10 µg 
Add to Cart
발현 숙주: Human Cells  
  • Slide 1
80476-R08H-50
80476-R08H-10
50 µg 
10 µg 
Add to Cart
반응성: Human  
신청: 
    10306-R005-50
    10306-R005-100
    10306-R005-1
    50 µg 
    100 µg 
    1 mg 
    Add to Cart
    반응성: Human  
    신청: ELISA  WB  
    • Slide 1
    10306-RP01-400
    10306-RP01-200
    10306-RP01-100
    400 µg 
    200 µg 
    100 µg 
    Add to Cart
    반응성: Human  
    신청: ELISA  
      10306-R204-50
      10306-R204-100
      50 µg 
      100 µg 
      Add to Cart
      반응성: Human  
      신청: 
        10306-R142-50
        10306-R142-100
        10306-R142-1
        50 µg 
        100 µg 
        1 mg 
        Add to Cart
        반응성: Human  
        신청: ELISA  
          10306-RP02-50
          10306-RP02-200
          10306-RP02-100
          50 µg 
          200 µg 
          100 µg 
          Add to Cart
          반응성: Rat  
          신청: ELISA  
            80476-RP01-400
            80476-RP01-200
            80476-RP01-100
            400 µg 
            200 µg 
            100 µg 
            Add to Cart
            반응성: Rat  
            신청: 
              80476-R005-50
              80476-R005-100
              50 µg 
              100 µg 
              Add to Cart
              반응성: Rat  
              신청: ELISA  
                80476-T16-50
                80476-T16-200
                80476-T16-100
                50 µg 
                200 µg 
                100 µg 
                Add to Cart

                SerpinA1 ELISA Pair Set

                검출 한계:
                SEK10306-5
                SEK10306-15
                5 Plates 
                15 Plates 
                Add to Cart

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                SerpinA1 cdna-clone 연구배경

                SerpinA1, also known as Alpha-1 antitrypsin (AAT), is a prototype member of the Serpin superfamily of the serine protease inhibitors. This serine protease inhibitor blocks the protease, neutrophil elastase. Alpha-1 antitrypsin is mainly produced in the liver and acts as an antiprotease. Its principal function is to inactivate neutrophil elastase, preventing tissue damage. SerpinA1 (alpha1-antitrypsin), an acute phase protein and the classical neutrophil elastase inhibitor, is localized within lipid rafts in primary human monocytes in vitro. It association with monocytes is inhibited by cholesterol depleting/efflux-stimulating agents (nystatin, filipin, MbetaCD (methyl-beta-cyclodextrin) and oxidized low-density lipoprotein (oxLDL) and conversely, enhanced by free cholesterol. Furthermore, SerpinA1/monocyte association per se depletes lipid raft cholesterol as characterized by the activation of extracellular signal-regulated kinase 2, formation of cytosolic lipid droplets, and a complete inhibition of oxLDL uptake by monocytes. Previous population studies have suggested that heterozygote status for the AAT gene (SerpinA1) is a risk factor for chronic rhinosinusitis with nasal polyposis (CRSwNP). Alpha-1 antitrypsin deficiency is a recently identified genetic disease that occurs almost as frequently as cystic fibrosis. It is caused by various mutations in the SerpinA1 gene, and has numerous clinical implications. Alpha-1 antitrypsin deficiency is an inherited disease affecting the lung and liver. In the liver, alpha-1 antitrypsin deficiency may manifest as benign neonatal hepatitis syndrome; a small percentage of adults develop liver fibrosis, with progression to cirrhosis and hepatocellular carcinoma. Its most important physiologic functions are the protection of pulmonary tissue from aggressive proteolytic enzymes and regulation of pulmonary immune processes.

                 SerpinA1 cdna-clone 참고자료
              • Khnlein T, et al. (2008) Alpha-1 antitrypsin deficiency: pathogenesis, clinical presentation, diagnosis, and treatment. Am J Med. 121(1): 3-9.
              • Camelier AA, et al. (2008) Alpha-1 antitrypsin deficiency: diagnosis and treatment. J Bras Pneumol. 34(7): 514-27.
              • Subramaniyam D, et al. (2010) Cholesterol rich lipid raft microdomains are gateway for acute phase protein, SERPINA1. Int J Biochem Cell Biol. 42(9): 1562-70.
              • Kilty SJ, et al. (2010) Polymorphisms in the SERPINA1 (Alpha-1-Antitrypsin) gene are associated with severe chronic rhinosinusitis unresponsive to medical therapy. Am J Rhinol Allergy. 24(1): e4-9.
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