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휴먼 JNK1 / MAPK8 transcript variant JNK1-b2 Gene ORF cDNA clone expression plasmid, N-Flag 태그

데이터시트리뷰프로토콜
발현 숙주: Baculovirus-Insect Cells  
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10795-H09B-50
10795-H09B-20
50 µg 
20 µg 
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반응성: Human  
신청: ELISA  
    10795-RP01-400
    10795-RP01-200
    10795-RP01-100
    400 µg 
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    반응성: Human  
    신청: IHC-P  IF  ICC/IF  
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    100960-T10-50
    100960-T10-200
    100960-T10-100
    50 µg 
    200 µg 
    100 µg 
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    반응성: Human  
    신청: 
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    10795-T54-50
    10795-T54-200
    10795-T54-100
    50 µg 
    200 µg 
    100 µg 
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    JNK1 / MAPK8 cdna-clone 연구배경

    Mitogen-activated protein kinase 8 (MAPK8), also known as JNK1, is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The protein kinases JNK1 has been found to serve as critical molecular links between obesity, metabolic inflammation, and disorders of glucose homeostasis. It is critically involved in the promotion of diet-induced obesity, metabolic inflammation and beta-cell dysfunction. The selective deficiency of JNK1 in the murine nervous system is sufficient to suppress diet-induced obesity. Genetic analysis indicates that the effects of JNK1 can be separated from effects of JNK1 on obesity. JNK1 is a potential pharmacological target for the development of drugs that might be useful for the treatment of metabolic syndrome, and type 2 diabetes. Furthermore, JNK1 plays a major role in the hypoxic cellular damage. JNK1 protein might be an attractive target for antihypoxic therapy in increasing resistance to many pathological conditions and diseases, leading to the oxygen deficit.

    휴먼 JNK1 / MAPK8 cdna-clone 참고자료
  • Betigeri S, et al. (2006) JNK1 as a molecular target to limit cellular mortality under hypoxia. Mol Pharm. 3(4): 424-30.
  • Solinas G, et al. (2010) JNK1 and IKKbeta: molecular links between obesity and metabolic dysfunction. FASEB J. 24(8): 2596-611.
  • Sabio G, et al. (2010) Role of the hypothalamic-pituitary-thyroid axis in metabolic regulation by JNK1. Genes Dev. 24(3): 256-64.
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