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휴먼 FGFR2/CD332 Gene ORF cDNA clone expression plasmid, N-Flag 태그

데이터시트리뷰프로토콜
발현 숙주: Human Cells  
  • Slide 1
16485-H08H-50
16485-H08H-200
50 µg 
200 µg 
Add to Cart
제품 설명: Active  
발현 숙주: Human Cells  
  • Slide 1
10824-H03H-50
10824-H03H-100
50 µg 
100 µg 
Add to Cart
발현 숙주: Human Cells  
  • Slide 1
16483-H08H-50
16483-H08H-200
50 µg 
200 µg 
Add to Cart
제품 설명: Active  
발현 숙주: Baculovirus-Insect Cells  
  • Slide 1
10824-H20B1-50
10824-H20B1-20
50 µg 
20 µg 
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제품 설명: Active  
발현 숙주: Human Cells  
  • Slide 1
10824-H08H-50
10824-H08H-100
50 µg 
100 µg 
Add to Cart
발현 숙주: Human Cells  
  • Slide 1
16485-H02H-50
16485-H02H-200
50 µg 
200 µg 
Add to Cart
발현 숙주: Human Cells  
  • Slide 1
51128-M08H-50
51128-M08H-100
50 µg 
100 µg 
Add to Cart
발현 숙주: Human Cells  
  • Slide 1
51128-M02H-50
51128-M02H-100
50 µg 
100 µg 
Add to Cart
반응성: Human  
신청: ELISA  
    10824-MM07-50
    10824-MM07-200
    10824-MM07-100
    50 µg 
    200 µg 
    100 µg 
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    반응성: Human  
    신청: 
      10824-MM02-50
      10824-MM02-200
      10824-MM02-100
      10824-MM02-1
      50 µg 
      200 µg 
      100 µg 
      1 mg 
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      반응성: Human  
      신청: ELISA  
        10824-RP02-50
        10824-RP02-200
        10824-RP02-100
        50 µg 
        200 µg 
        100 µg 
        Add to Cart
        반응성: Human  
        신청: ELISA  
          10824-RP01-400
          10824-RP01-200
          10824-RP01-100
          400 µg 
          200 µg 
          100 µg 
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          반응성: Human  
          신청: 
            10824-MM10-50
            10824-MM10-200
            10824-MM10-100
            10824-MM10-1
            50 µg 
            200 µg 
            100 µg 
            1 mg 
            Add to Cart
            반응성: Human  
            신청: ELISA  
              10824-T16-50
              10824-T16-200
              10824-T16-100
              50 µg 
              200 µg 
              100 µg 
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              반응성: Human  
              신청: ELISA  
                10824-R016-50
                10824-R016-100
                50 µg 
                100 µg 
                Add to Cart

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                FGFR2/CD332 cdna-clone 연구배경

                FGFR2, also known as CD332, belongs to the fibroblast growth factor receptor subfamily where amino acid sequence is highly conserved between members and throughout evolution. FGFR2 acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. It is required for normal embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis and skin development. FGFR2 plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. It also promotes cell proliferation in keratinocytes and imature osteoblasts, but promotes apoptosis in differentiated osteoblasts. FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation. Mutations that lead to constitutive kinase activation or impair normal CD332 maturation, internalization and degradation lead to aberrant signaling. Over-expressed FGFR2 promotes activation of STAT1. Defects in CD3322 are the cause of Crouzon syndrome, Jackson-Weiss syndrome, Apert syndrome, Pfeiffer syndrome, Beare-Stevenson cutis gyrata syndrome, familial scaphocephaly syndrome, lacrimo-auriculo-dento-digital syndrome and Antley-Bixler syndrome without genital anomalies or disordered steroidogenesis.

                Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

                휴먼 FGFR2/CD332 cdna-clone 참고자료
              • Marie PJ, et al. (2003) Regulation of human cranial osteoblast phenotype by FGF-2, FGFR-2 and BMP-2 signaling. Histol. 17(3):877-85.
              • Park WJ, et al. (1996) Novel FGFR2 mutations in Crouzon and Jackson-Weiss syndromes show allelic heterogeneity and phenotypic variability. Hum Mol Genet. 4(7):1229-33.
              • Orr-Urtreger A, et al. (1993) Developmental localization of the splicing alternatives of fibroblast growth factor receptor-2 (FGFR2). Dev Biol. 158(2):475-86.
              • 주의 : 모든 제품은 "연구 목적만을 위한 것이며 진단이나 치료에 사용하도록 의도되지 않았습니다".