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휴먼 Progranulin/Granulin Gene ORF cDNA clone expression plasmid, N-Flag 태그

데이터시트리뷰프로토콜
발현 숙주: Human Cells  
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10826-H08H-50
10826-H08H-100
50 µg 
100 µg 
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발현 숙주: Human Cells  
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50396-M08H-50
50396-M08H-100
50 µg 
100 µg 
Add to Cart
반응성: Human  
신청: ELISA  IHC-P  
  • Slide 1
  • Slide 1
10826-RP04-50
10826-RP04-200
10826-RP04-100
50 µg 
200 µg 
100 µg 
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반응성: Human  
신청: ELISA  IF  ICC/IF  
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10826-MM02-50
10826-MM02-200
10826-MM02-100
10826-MM02-1
50 µg 
200 µg 
100 µg 
1 mg 
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반응성: Human  
신청: 
    10826-MM10-50
    10826-MM10-200
    10826-MM10-100
    10826-MM10-1
    50 µg 
    200 µg 
    100 µg 
    1 mg 
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    반응성: Human  
    신청: ELISA  
      10826-R007-50
      10826-R007-100
      50 µg 
      100 µg 
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      반응성: Human  
      신청: ELISA  
      • Slide 1
      10826-RP03-400
      10826-RP03-200
      10826-RP03-100
      400 µg 
      200 µg 
      100 µg 
      Add to Cart
      반응성: Mouse  
      신청: 
        50396-R019-50
        50396-R019-100
        50396-R019-1
        50 µg 
        100 µg 
        1 mg 
        Add to Cart
        반응성: Mouse  
        신청: ELISA  
          50396-R017-50
          50396-R017-100
          50 µg 
          100 µg 
          Add to Cart
          반응성: Mouse  
          신청: ELISA  IHC-P  
          • Slide 1
          • Slide 1
          50396-RP02-50
          50396-RP02-200
          50396-RP02-100
          50 µg 
          200 µg 
          100 µg 
          Add to Cart
          반응성: Mouse  
          신청: ELISA  
            50396-R034-50
            50396-R034-100
            50396-R034-1
            50 µg 
            100 µg 
            1 mg 
            Add to Cart
            반응성: Mouse  
            신청: ELISA  
              50396-RP01-400
              50396-RP01-200
              50396-RP01-100
              400 µg 
              200 µg 
              100 µg 
              Add to Cart

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              Progranulin/Granulin cdna-clone 연구배경

              &Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis. Granulins have possible cytokine-like activity. They may play a role in inflammation, wound repair, and tissue remodeling. Granulin-4 promotes proliferation of the epithelial cell line A431 in culture while granulin-3 acts as an antagonist to granulin-4, inhibiting the growth. Granulin expression inhibited Tat transactivation, and tethering experiments showed that this effect was due, at least in part, to a direct action on cyclin T1 in the absence of Tat.

              휴먼 Progranulin/Granulin cdna-clone 참고자료
            • Hoque M, et al. (2003) The growth factor granulin interacts with cyclin T1 and modulates P-TEFb-dependent transcription. Mol Cell Biol. 23(5): 1688-702.
            • Bateman A, et al. (1990) Granulins, a novel class of peptide from leukocytes. Biochem Biophys Res Commun. 173(3): 1161-8.
            • Trinh DP, et al. (1999) Epithelin/granulin growth factors: extracellular cofactors for HIV-1 and HIV-2 Tat proteins. Biochem Biophys Res Commun. 256(2): 299-306.
            • 주의 : 모든 제품은 "연구 목적만을 위한 것이며 진단이나 치료에 사용하도록 의도되지 않았습니다".