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휴먼 P4HB Gene ORF cDNA clone expression plasmid, N-Flag 태그

데이터시트리뷰프로토콜
발현 숙주: Human Cells  
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10827-H08H-50
10827-H08H-100
50 µg 
100 µg 
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발현 숙주: Human Cells  
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50638-M08H-50
50638-M08H-100
50 µg 
100 µg 
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반응성: Human  
신청: 
    10827-MM12-50
    10827-MM12-200
    10827-MM12-100
    10827-MM12-1
    50 µg 
    200 µg 
    100 µg 
    1 mg 
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    반응성: Human  
    신청: ELISA  IHC-P  
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    10827-MM08-50
    10827-MM08-200
    10827-MM08-100
    10827-MM08-1
    50 µg 
    200 µg 
    100 µg 
    1 mg 
    Add to Cart
    반응성: Human  
    신청: ELISA  IF  IP  ICC/IF  
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    10827-R016-50
    10827-R016-100
    50 µg 
    100 µg 
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    반응성: Human  
    신청: ELISA  WB  IHC-P  IP  
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    10827-RP02-50
    10827-RP02-200
    10827-RP02-100
    50 µg 
    200 µg 
    100 µg 
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    반응성: Human  
    신청: ELISA  WB  
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    10827-RP01-400
    10827-RP01-200
    10827-RP01-100
    400 µg 
    200 µg 
    100 µg 
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    반응성: Human  
    신청: FCM  IF  ICC/IF  
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    10827-MM03-50
    10827-MM03-200
    10827-MM03-100
    50 µg 
    200 µg 
    100 µg 
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    반응성: Human  
    신청: FCM  
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    10827-R016-F-25
    10827-R016-F-100
    25 Test 
    100 Tests 
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    반응성: Human  
    신청: FCM  
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    10827-MM03-F-25
    10827-MM03-F-100
    25 Test 
    100 Tests 
    Add to Cart
    반응성: Mouse  
    신청: ELISA  WB  IHC-P  IP  
    • Slide 1
    • Slide 1
    • Slide 1
    • Slide 1
    50638-RP02-50
    50638-RP02-200
    50638-RP02-100
    50 µg 
    200 µg 
    100 µg 
    Add to Cart
    반응성: Mouse  
    신청: IHC-P  
    • Slide 1
    • Slide 1
    • Slide 1
    50638-R023-50
    50638-R023-100
    50 µg 
    100 µg 
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    반응성: Mouse  
    신청: ELISA  
      50638-RP01-400
      50638-RP01-200
      50638-RP01-100
      400 µg 
      200 µg 
      100 µg 
      Add to Cart

      P4HB ELISA Pair Set

      검출 한계: 46.88 pg/ml
      SEK10827-5
      SEK10827-15
      5 Plates 
      15 Plates 
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      P4HB cdna-clone 연구배경

      Protein disulfide-isomerase, also known as Cellular thyroid hormone-binding protein, Prolyl 4-hydroxylase subunit beta, p55 and P4HB, is a peripheral membrane protein which belongs to the protein disulfide isomerase family. P4HB is highly abundant. In some cell types, it seems to be also secreted or associated with the plasma membrane, where it undergoes constant shedding and replacement from intracellular sources. P4HB localizes near CD4-enriched regions on lymphoid cell surfaces. It is identified by mass spectrometry in melanosome fractions from stage I to stage IV. P4HB reduces and may activate fusogenic properties of HIV-1 gp120 surface protein, thereby enabling HIV-1 entry into the cell. P4HB catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, it seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. P4HB may therefore cause structural modifications of exofacial proteins. Inside the cell, it seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, P4HB functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, it facilitates aggregation (anti-chaperone activity). P4HB may be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. It also acts a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP.

      휴먼 P4HB cdna-clone 참고자료
    • Kivirikko KI, et al., 1989, FASEB J., 3 (5): 1609-17.
    • Pihlajaniemi T, et al.,1991, J Hepatol., 13, Suppl 3: S2
    • Fenouillet E., et al., 2001, J. Infect. Dis. 183:744-752.
    • Gevaert K., et al., 2003, Nat. Biotechnol. 21:566-569.
    • Barbouche R., et al., 2003, J. Biol. Chem. 278:3131-3136.
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