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휴먼 CXCL16 / SR-PSOX Gene ORF cDNA clone expression plasmid, N-Flag 태그

데이터시트리뷰프로토콜
발현 숙주: Human Cells  
  • Slide 1
50142-M08H-50
50142-M08H-20
50 µg 
20 µg 
Add to Cart
발현 숙주: Yeast  
  • Slide 1
50142-M08Y-20
50142-M08Y-100
20 µg 
100 µg 
Add to Cart
발현 숙주: Human Cells  
  • Slide 1
80149-R02H-50
80149-R02H-20
50 µg 
20 µg 
Add to Cart
발현 숙주: Human Cells  
  • Slide 1
80149-R08H-50
80149-R08H-20
50 µg 
20 µg 
Add to Cart
발현 숙주: Human Cells  
  • Slide 1
70060-D08H-50
70060-D08H-20
50 µg 
20 µg 
Add to Cart
발현 숙주: Human Cells  
  • Slide 1
70060-D02H-50
70060-D02H-20
50 µg 
20 µg 
Add to Cart
반응성: Mouse  
신청: ELISA  WB  
  • Slide 1
50142-T48-50
50142-T48-200
50142-T48-100
50 µg 
200 µg 
100 µg 
Add to Cart
반응성: Mouse  
신청: ELISA  
    50142-RP01-400
    50142-RP01-200
    50142-RP01-100
    400 µg 
    200 µg 
    100 µg 
    Add to Cart
    반응성: Rat  
    신청: ELISA  
      80149-T16-50
      80149-T16-200
      80149-T16-100
      50 µg 
      200 µg 
      100 µg 
      Add to Cart
      반응성: Rat  
      신청: ELISA  
        80149-MM02-50
        80149-MM02-200
        80149-MM02-100
        50 µg 
        200 µg 
        100 µg 
        Add to Cart

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        CXCL16 / SR-PSOX cdna-clone 연구배경

        C-X-C motif chemokine 16, also known as Small-inducible cytokine B16, SR-PSOX, and CXCL16, is a single-pass type I membrane protein which belongs to the intercrine alpha (chemokine CxC) family. CXCL16 exists in transmembrane and soluble forms. The transmembrane form acts as a scavenger receptor for oxidised LDL whereas the soluble form acts a chemoattractant for mainly CD8+ T cells. CXCL16 is a protein which shares pattern recognition receptor functions, relevant for adhesion and phagocytosis of bacterial products, with the properties of an adhesion molecule and inflammatory chemokine. CXCL16/SR-PSOX is an interferon-gamma-regulated chemokine and scavenger receptor for oxidized low-density lipoprotein that is expressed in atherosclerotic lesions. Proteolytic cleavage of membrane-bound CXCL16 releases soluble CXCL16, which may promote migration of effector T cells and augment a proatherogenic inflammatory response. CXCL16/SR-PSOX can be a potential player in atherogenesis. Enhanced expression of CXCL16 has been demonstrated in atherosclerotic plaques and several properties have been attributed to CXCL16 that could influence the atherosclerotic process. Following in vitro studies suggested that as an adhesion molecule CXCL16/SR-PSOX might mediate T-cell adhesion to the endothelium, as a chemokine-drive T-cell migration, stimulate cell proliferation and elicit inflammatory phenotype in smooth muscle cells (SMC) and, finally, as a scavenger receptor-mediate uptake of atherogenic lipoproteins by macrophages and SMC. CXCR6 and its ligand CXCL16 in regulating metastasis and invasion of cancer. CXCR6 and CXCL16 are up-regulated in multiple cancer tissue types and cancer cell lines relative to normal tissues and cell lines. In addition, both CXCR6 and CXCL16 levels increase as tumor malignancy increases. Thus, CXCL16 and CXCR6 may mark cancers arising in an inflammatory milieu and mediate pro-tumorigenic effects of inflammation through direct effects on cancer cell growth and by inducing the migration and proliferation of tumor-associated leukocytes.

        휴먼 CXCL16 / SR-PSOX cdna-clone 참고자료
      • Sheikine Y, et al. (2008) CXCL16/SR-PSOX--a friend or a foe in atherosclerosis? Atherosclerosis. 197(2): 487-95.
      • Lehrke M, et al. (2008) CXCL16 is a surrogate marker of inflammatory bowel disease. Scand J Gastroenterol. 43(3): 283-8.
      • Jansson AM, et al. (2009) Soluble CXCL16 predicts long-term mortality in acute coronary syndromes. Circulation. 119(25): 3181-8.
      • Darash-Yahana M, et al. (2009) The chemokine CXCL16 and its receptor, CXCR6, as markers and promoters of inflammation-associated cancers. PLoS One. 4(8): e6695.
      • Deng L, et al. (2010) CXCR6/CXCL16 functions as a regulator in metastasis and progression of cancer. Biochim Biophys Acta. 1806(1): 42-9.
      • 주의 : 모든 제품은 "연구 목적만을 위한 것이며 진단이나 치료에 사용하도록 의도되지 않았습니다".