Text Size:AAA

휴먼 HPRG/HRG Gene ORF cDNA clone expression plasmid, N-Flag 태그

데이터시트리뷰프로토콜
제품 설명: Active  
발현 숙주: Human Cells  
  • Slide 1
10836-H08H-50
10836-H08H-20
10836-H08H-100
50 µg 
20 µg 
100 µg 
Add to Cart
발현 숙주: Human Cells  
  • Slide 1
81643-R08H-20
81643-R08H-100
20 µg 
100 µg 
Add to Cart
반응성: Human  
신청: ELISA  
    10836-R028-50
    10836-R028-100
    50 µg 
    100 µg 
    Add to Cart
    반응성: Human  
    신청: ELISA  
      10836-RP04-50
      10836-RP04-200
      10836-RP04-100
      50 µg 
      200 µg 
      100 µg 
      Add to Cart
      반응성: Human  
      신청: ELISA  
        10836-MM01-50
        10836-MM01-200
        10836-MM01-100
        10836-MM01-1
        50 µg 
        200 µg 
        100 µg 
        1 mg 
        Add to Cart
        반응성: Human  
        신청: ELISA  
          10836-MM02-50
          10836-MM02-200
          10836-MM02-100
          50 µg 
          200 µg 
          100 µg 
          Add to Cart
          반응성: Human  
          신청: ELISA  
            10836-RP03-400
            10836-RP03-200
            10836-RP03-100
            400 µg 
            200 µg 
            100 µg 
            Add to Cart

            HPRG/HRG ELISA Pair Set

            검출 한계: 10.94 pg/ml
            SEK10836-5
            SEK10836-15
            5 Plates 
            15 Plates 
            Add to Cart

            HPRG/HRG cDNA ORF CloneRelated Products

            Related Products

            Featured Reagent Products

            HPRG/HRG cdna-clone 연구배경

            Histidine-rich glycoprotein, also known as HRG and HPRG, is a glycoprotein located in plasma and platelets, and contains an unusually large amount of histidine and proline. In human, five distinct domains are recognized in the mature HPRG molecule. There are two N-terminal cystatin-like modules (aa 19 - 254) and one His-Pro-rich region (aa 350 - 497) that is flanked by two Pro-rich segments (aa 276 - 321 and 498 - 525). The His-Pro-rich region contains 10 tandem repeats with an HHPHG motif, and the N- and C-termini are linked by a disulfide bond. The specific functions of HRG remain unclear, but it is known that the protein binds heme, dyes and divalent metal ions. It inhibits rosette formation and interacts with heparin, thrombospondin and plasminogen. Two of the protein's effects, the inhibition of fibrinolysis and the reduction of inhibition of coagulation, indicate a potential prothrombotic effect. HPRG is evolutionarily, functionally and structurally related to cleaved high molecular weight kininogen (HKa), an anti-angiogenic polypeptide that stimulates apoptosis of proliferating endothelial cells through binding to cell-surface tropomyosin. The antiangiogenic activity of the multidomain plasma protein HPRG is localized to its histidine-proline-rich (H/P) domain and has recently been shown to be mediated, at least partially, through binding to cell-surface tropomyosin in fibroblast growth factor-2-activated endothelial cells.

            휴먼 HPRG/HRG cdna-clone 참고자료
          • Guan X, et al. (2004) Histidine-proline rich glycoprotein (HPRG) binds and transduces anti-angiogenic signals through cell surface tropomyosin on endothelial cells. Thromb Haemost. 92(2): 403-12.
          • Doate F, et al. (2004) Peptides derived from the histidine-proline domain of the histidine-proline-rich glycoprotein bind to tropomyosin and have antiangiogenic and antitumor activities. Cancer Res. 64(16): 5812-7.
          • 주의 : 모든 제품은 "연구 목적만을 위한 것이며 진단이나 치료에 사용하도록 의도되지 않았습니다".