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휴먼 CD150 / SLAM / SLAMF1 Gene ORF cDNA clone expression plasmid, N-Flag 태그

데이터시트리뷰프로토콜
제품 설명: Active  
발현 숙주: Human Cells  
  • Slide 1
10837-H08H-50
10837-H08H-100
50 µg 
100 µg 
Add to Cart
발현 숙주: Human Cells  
  • Slide 1
80349-R02H-50
80349-R02H-100
50 µg 
100 µg 
Add to Cart
발현 숙주: Human Cells  
  • Slide 1
80349-R08H-50
80349-R08H-100
50 µg 
100 µg 
Add to Cart
반응성: Human  
신청: ELISA  WB  
  • Slide 1
10837-RP02-400
10837-RP02-200
10837-RP02-100
400 µg 
200 µg 
100 µg 
Add to Cart
반응성: Human  
신청: 
    10837-MM02-50
    10837-MM02-200
    10837-MM02-100
    10837-MM02-1
    50 µg 
    200 µg 
    100 µg 
    1 mg 
    Add to Cart
    반응성: Human  
    신청: ELISA  IHC-P  
    • Slide 1
    • Slide 1
    • Slide 1
    10837-R008-50
    10837-R008-100
    50 µg 
    100 µg 
    Add to Cart
    반응성: Human  
    신청: ELISA  
      10837-MM05-50
      10837-MM05-200
      10837-MM05-100
      50 µg 
      200 µg 
      100 µg 
      Add to Cart
      반응성: Human  
      신청: 
        10837-R110-50
        10837-R110-100
        10837-R110-1
        50 µg 
        100 µg 
        1 mg 
        Add to Cart
        반응성: Human  
        신청: ELISA  IHC-P  
        • Slide 1
        • Slide 1
        10837-RP01-50
        10837-RP01-200
        10837-RP01-100
        50 µg 
        200 µg 
        100 µg 
        Add to Cart
        반응성: Rat  
        신청: ELISA  
          80349-RP01-400
          80349-RP01-200
          80349-RP01-100
          400 µg 
          200 µg 
          100 µg 
          Add to Cart
          반응성: Rat  
          신청: ELISA  
            80349-T16-50
            80349-T16-200
            80349-T16-100
            50 µg 
            200 µg 
            100 µg 
            Add to Cart

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            CD150 / SLAM / SLAMF1 cdna-clone 연구배경

            CD150/signaling lymphocytic activation molecule (SLAM) is a cell surface sialylated phosphoglycoprotein and belongs to the CD2 subset of the Ig superfamily of type I transmembrane glycoproteins. The CD150 receptor is expressed on thymocytes, activated and memory T cells, B cells, platelets, natural killer T cells, and mature dendritic cells, and is also detected on tumor cells of Hodgkin's lymphoma (HL) and diffuse large B-cell lymphoma with an activated B cell phenotype. Additionally, it is the immune cell receptor for measles virus (MV). As a self-ligand, CD150 performs diverse immunologic functions including T/B-cell costimulation, induction of IFN-&gamma in Th1 T-cell clones, redirection of Th2 clones to a Th1 or Th0 phenotype, and inhibition of apoptosis in B cells. Furthermore, CD150 was shown to be the second receptor for measles virus in addition to CD46, and the distribution of SLAM on various cell lines is consistent with their susceptibility to clinical isolates of measles virus.

            휴먼 CD150 / SLAM / SLAMF1 cdna-clone 참고자료
          • Tatsuo H, et al. (2002) The morbillivirus receptor SLAM (CD150). Microbiol Immunol. 46(3): 135-42.
          • Sidorenko SP, et al. (2003)The dual-function CD150 receptor subfamily: the viral attraction. Nat Immunol. 4(1): 19-24.
          • Yurchenko MY, et al. (2010) CD150 regulates JNK1/2 activation in normal and Hodgkin's lymphoma B cells. Immunol Cell Biol. 88(5): 565-74.
          • Leonard VH, et al. (2010) Measles virus selectively blind to signaling lymphocytic activation molecule (SLAM ; CD150) is attenuated and induces strong adaptive immune responses in rhesus monkeys. J Virol. 84(7): 3413-20.
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