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쥐 TGM2 / Transglutaminase 2 Gene ORF cDNA clone expression plasmid

데이터시트리뷰프로토콜
발현 숙주: Baculovirus-Insect Cells  
  • Slide 1
11095-H07B-50
11095-H07B-100
50 µg 
100 µg 
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반응성: Human  
신청: ELISA  
    11095-R013-50
    11095-R013-100
    50 µg 
    100 µg 
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    반응성: Human  
    신청: ELISA  
      11095-RP01-400
      11095-RP01-200
      11095-RP01-100
      400 µg 
      200 µg 
      100 µg 
      Add to Cart
      반응성: Human  
      신청: ELISA  WB  IP  
      • Slide 1
      • Slide 1
      11095-RP02-50
      11095-RP02-200
      11095-RP02-100
      50 µg 
      200 µg 
      100 µg 
      Add to Cart

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      TGM2 / Transglutaminase 2 cdna-clone 연구배경

      Protein-glutamine gamma-glutamyltransferase 2, also known as Tissue transglutaminase, Transglutaminase C, Transglutaminase-2, and TGM2, is a member of the transglutaminase superfamily. TGM2 plays a role in cell growth and survival through the anti-apoptosis signaling pathway. It is a calcium-dependent acyltransferase which also undergoes a GTP-binding/GTPase cycle even though it lacks any obvious sequence similarity with canonical GTP-binding (G) proteins. TGM2 is a multi-functional protein which catalyzes transamidation reactions or acts as a G-protein in intracellular signalling. As an enzyme which is responsible for the majority of transglutaminase (TG) activity in the brain, TGM2 is likely to play a modulatory role in nervous system development and has regulatory effect on neuronal cell death as well. Most importantly, numerous studies have presented data demonstrating that dysregulation of TGM2 may contribute to the pathogenesis of many neurodegenerative disorders, including Huntington's disease, Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis as well as nervous system injuries.

       TGM2 / Transglutaminase 2 cdna-clone 참고자료
    • Ruan Q, et al. (2007) Transglutaminase 2 in neurodegenerative disorders. Front Biosci. 12: 891-904.
    • Ai L, et al. (2008) The transglutaminase 2 gene (TGM2), a potential molecular marker for chemotherapeutic drug sensitivity, is epigenetically silenced in breast cancer. Carcinogenesis. 29(3): 510-8.
    • Filiano AJ, et al. (2010) Transglutaminase 2 protects against ischemic stroke. Neurobiol Dis. 39(3): 334-43.
    • Park D, et al. (2010) Transglutaminase 2: a multi-functional protein in multiple subcellular compartments. Amino Acids. 39(3): 619-31.
    • Miyoshi N, et al. (2010) TGM2 is a novel marker for prognosis and therapeutic target in colorectal cancer. Ann Surg Oncol. 17(4): 967-72.
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