Text Size:AAA

휴먼 CD113/Nectin-3 Gene ORF cDNA clone expression plasmid, N-Flag 태그

데이터시트리뷰프로토콜
제품 설명: Active  
발현 숙주: Human Cells  
  • Slide 1
10852-H08H-50
10852-H08H-100
50 µg 
100 µg 
Add to Cart
반응성: Human  
신청: IHC-P  
  • Slide 1
  • Slide 1
  • Slide 1
10852-MM02-50
10852-MM02-200
10852-MM02-100
50 µg 
200 µg 
100 µg 
Add to Cart
반응성: Human  
신청: ELISA  
    10852-T16-50
    10852-T16-200
    10852-T16-100
    50 µg 
    200 µg 
    100 µg 
    Add to Cart
    반응성: Human  
    신청: ELISA  
      10852-RP01-400
      10852-RP01-200
      10852-RP01-100
      400 µg 
      200 µg 
      100 µg 
      Add to Cart
      반응성: Human  
      신청: ELISA  
        10852-MM04-50
        10852-MM04-200
        10852-MM04-100
        50 µg 
        200 µg 
        100 µg 
        Add to Cart
        반응성: Human  
        신청: ELISA  WB  
        • Slide 1
        10852-RP02-50
        10852-RP02-200
        10852-RP02-100
        50 µg 
        200 µg 
        100 µg 
        Add to Cart

        CD113/Nectin-3 cDNA ORF CloneRelated Products

        Related Products

        Featured Reagent Products

        CD113/Nectin-3 cdna-clone 연구배경

        Poliovirus receptor-related 3 (PVRL3), also known as Nectin-3 and CD113, is a member of the nectin family. PVRL3/Nectin-3 is an 83 kDa, type I transmembrane glycoprotein. Its precursor is 549 amino acids (aa) in length and contains an extended signal sequence of 57 aa, an extracellular domain (ECD) of 347 aa, a transmembrane segment of 21 aa, and a cytoplasmic region of 124 aa. Nectin-3 has three splicing variants, nectin-3alpha (biggest), -3beta (middle), and -3gamma (smallest). It is predominantly expressed in testis and placenta as well as in various cell lines, including epithelial cell lines. PVRL3/Nectin-3 plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with PVRL2/Nectin-2 at Sertoli-spermatid junctions. PVRL3/Nectin-3 is thus involved in the formation of cell-cell junctions, including adherens junctions and synapses. It has been shown to induce endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation.

        휴먼 CD113/Nectin-3 cdna-clone 참고자료
      • Satoh-Horikawa, et al. (2000). Nectin-3, a new member of immunoglobulin-like cell adhesion molecules that shows homophilic and heterophilic cell-cell adhesion activities. J Biol Chem (UNITED STATES) . 275 (14): 10291-9.
      • Reymond N, et al. (2000). Human nectin3/PRR3: a novel member of the PVR/PRR/nectin family that interacts with afadin. Gene (NETHERLANDS). 255 (2): 347-55.
      • 주의 : 모든 제품은 "연구 목적만을 위한 것이며 진단이나 치료에 사용하도록 의도되지 않았습니다".