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휴먼 IL32 transcript variant 1 Gene ORF cDNA clone expression plasmid, N-Flag 태그

데이터시트리뷰프로토콜
발현 숙주: Human Cells  
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11064-H08H-50
11064-H08H-100
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100 µg 
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반응성: Human  
신청: WB  
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11064-MM12-50
11064-MM12-200
11064-MM12-100
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200 µg 
100 µg 
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반응성: Human  
신청: 
    11064-R034-50
    11064-R034-100
    11064-R034-1
    50 µg 
    100 µg 
    1 mg 
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    반응성: Human  
    신청: WB  IP  
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    100285-T36-50
    100285-T36-200
    100285-T36-100
    50 µg 
    200 µg 
    100 µg 
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    반응성: Human  
    신청: ELISA  WB  
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    11064-T48-50
    11064-T48-200
    11064-T48-100
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    200 µg 
    100 µg 
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    반응성: Human  
    신청: ELISA  
      11064-RP01-400
      11064-RP01-200
      11064-RP01-100
      400 µg 
      200 µg 
      100 µg 
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      반응성: Human  
      신청: ELISA  
        11064-R030-50
        11064-R030-100
        50 µg 
        100 µg 
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        반응성: Human  
        신청: ELISA  
          11064-T16-50
          11064-T16-200
          11064-T16-100
          50 µg 
          200 µg 
          100 µg 
          Add to Cart
          반응성: Human  
          신청: ELISA  
            11064-R403-50
            11064-R403-100
            11064-R403-1
            50 µg 
            100 µg 
            1 mg 
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            IL32 cdna-clone 연구배경

            IL-32 is a recently discovered cytokine that induces various proinflammatory cytokines (TNF-alpha, IL-1beta, IL-6) and chemokines in both human and mouse cells through the NF-kappaB and p38 MAPK inflammatory signal pathways. It is regulated robustly by other major proinflammatory cytokines, and is crucial to inflammation and immune responses. Four of the IL-32 isoforms (alpha, beta, gamma and delta) are the most representative IL-32 transcripts, and gamma isoform of IL-32 is the most active, although all isoforms are biologically active. IL-32, a cytokine produced mainly by T, natural killer, and epithelial cells induces significant amounts of TNFalpha and MIP-2 and increases the production of both cytokines in a dose-dependent manner. IL-32 has been implicated in inflammatory disorders, mycobacterium tuberculosis infections, inflammatory bowel disease, and influenza A virus infection, as well as in some autoimmune diseases, such as rheumatoid arthritis, ulcerative colitis and in human stomach cancer, human lung cancer and breast cancer tissues. Thus, IL-32 expression might be valuable as a biomarker for cancer.

            휴먼 IL32 cdna-clone 참고자료
          • Felaco P, et al. (2009) IL-32: a newly-discovered proinflammatory cytokine. J Biol Regul Homeost Agents. 23(3): 141-7.
          • Kobayashi H, et al. (2009) Molecular characterization of IL-32 in human endothelial cells. Cytokine. 46(3): 351-8.
          • Meyer N, et al. (2010) IL-32 is expressed by human primary keratinocytes and modulates keratinocyte apoptosis in atopic dermatitis. J Allergy Clin Immunol. 125(4): 858-865.
          • 주의 : 모든 제품은 "연구 목적만을 위한 것이며 진단이나 치료에 사용하도록 의도되지 않았습니다".