Text Size:AAA

쥐 Cathepsin B/CTSB Gene ORF cDNA clone expression plasmid

데이터시트리뷰프로토콜
제품 설명: Active  
발현 숙주: Human Cells  
  • Slide 1
10483-H08H-20
10483-H08H-10
20 µg 
10 µg 
Add to Cart
제품 설명: Active  
발현 숙주: Human Cells  
  • Slide 1
50084-M08H-20
50084-M08H-10
20 µg 
10 µg 
Add to Cart
발현 숙주: Human Cells  
  • Slide 1
80545-R08H-50
80545-R08H-10
50 µg 
10 µg 
Add to Cart
반응성: Human  
신청: ELISA  IHC-P  
  • Slide 1
10483-T24-50
10483-T24-100
50 µg 
100 µg 
Add to Cart
반응성: Human  
신청: WB  IHC  IP  
  • Slide 1
  • Slide 1
  • Slide 1
  • Slide 1
  • Slide 1
10483-RP02-50
10483-RP02-200
10483-RP02-100
50 µg 
200 µg 
100 µg 
Add to Cart
반응성: Human  
신청: ELISA  
    10483-RP01-400
    10483-RP01-200
    10483-RP01-100
    400 µg 
    200 µg 
    100 µg 
    Add to Cart
    반응성: Mouse  
    신청: ELISA  
      50084-R004-50
      50084-R004-100
      50 µg 
      100 µg 
      Add to Cart
      반응성: Mouse  
      신청: IHC-P  
      • Slide 1
      • Slide 1
      50084-R010-50
      50084-R010-100
      50 µg 
      100 µg 
      Add to Cart
      반응성: Mouse  
      신청: 
        50084-T16-50
        50084-T16-200
        50084-T16-100
        50 µg 
        200 µg 
        100 µg 
        Add to Cart
        반응성: Mouse  
        신청: ELISA  
          50084-RP01-400
          50084-RP01-200
          50084-RP01-100
          400 µg 
          200 µg 
          100 µg 
          Add to Cart

          Cathepsin B/CTSB cDNA ORF CloneRelated Products

          Related Products

          Featured Reagent Products

          Cathepsin B/CTSB cdna-clone 연구배경

          Cathepsin B is a papain-family cysteine protease that is normally located in lysosomes, where it is involved in the turnover of proteins and plays various roles in maintaining the normal metabolism of cells. This protease has been implicated in pathological conditions, e.g., tumor progression and arthritis. In disease conditions, increases in the expression of cathepsin B occur at both the gene and protein levels. Cathepsin B is synthesized as a preproenzyme and the primary pathways for its normal trafficking to the lysosome utilize mannose 6-phosphate receptors (MPRs). Mature cathepsin B has the ability to degrade several extracellular matrix components at both neutral and acidic pH and has been implicated in the progression of several human and rodent tumors progression and arthritis. Cathepsin B expression is increased in many human cancers at the mRNA, protein and activity levels. It is also frequently overexpressed in premalignant lesions, an observation that associates this protease with local invasive stages of cancer. Increased expression of cathepsin B in primary cancers, and especially in preneoplastic lesions, suggests that this enzyme might have pro-apoptotic features. Active cathepsin B is also secreted from tumours, a mechanism likely to be facilitated by lysosomal exocytosis or extracellular processing by surface activators. Cathepsin B is localized to caveolae on the tumour surface, where binding to the annexin II heterotetramer occurs. Thus CTSB is suggested as a tumor marker. Additionally, Cathepsin B can degrade extracellular matrix proteins, such as collagen IV and laminin, and can activate the precursor form of urokinase plasminogen activator (uPA), perhaps thereby initiating an extracellular proteolytic cascade.

           Cathepsin B/CTSB cdna-clone 참고자료
        • Mai J, et al. (2000) Cell surface complex of cathepsin B/annexin II tetramer in malignant progression. Biochim Biophys Acta. 1477(1-2): 215-30.
        • Podgorski I, et al. (2003) Cathepsin B and its role(s) in cancer progression. Biochem Soc Symp. (70): 263-76.
        • Yan S, et al. (2003) Molecular regulation of human cathepsin B: implication in pathologies. Biol Chem. 384(6): 845-54.
        • Roshy S, et al. (2003) Pericellular cathepsin B and malignant progression. Cancer Metastasis Rev. 22(2-3): 271-86.
        •  

          주의 : 모든 제품은 "연구 목적만을 위한 것이며 진단이나 치료에 사용하도록 의도되지 않았습니다".