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휴먼 CXCL1 Gene ORF cDNA clone expression plasmid, N-Flag 태그

데이터시트리뷰프로토콜
발현 숙주: E. coli  
  • Slide 1
10877-H28E-50
10877-H28E-20
50 µg 
20 µg 
Add to Cart
발현 숙주: E. coli  
  • Slide 1
10877-HNCE-50
10877-HNCE-20
50 µg 
20 µg 
Add to Cart
발현 숙주: E. coli  
  • Slide 1
10877-H24E-50
10877-H24E-20
50 µg 
20 µg 
Add to Cart
발현 숙주: E. coli  
  • Slide 1
50150-MNCE-50
50150-MNCE-20
50 µg 
20 µg 
Add to Cart
발현 숙주: E. coli  
  • Slide 1
80039-RNCE-5
80039-RNCE-20
80039-RNCE-100
5 µg 
20 µg 
100 µg 
Add to Cart
반응성: Human  
신청: ELISA  
    10877-T16-50
    10877-T16-200
    10877-T16-100
    50 µg 
    200 µg 
    100 µg 
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    반응성: Human  
    신청: 
      10877-R012-50
      10877-R012-100
      50 µg 
      100 µg 
      Add to Cart
      반응성: Human  
      신청: WB  IP  
      • Slide 1
      • Slide 1
      100288-T36-50
      100288-T36-200
      100288-T36-100
      50 µg 
      200 µg 
      100 µg 
      Add to Cart
      반응성: Human  
      신청: WB  
      • Slide 1
      100288-T32-50
      100288-T32-200
      100288-T32-100
      50 µg 
      200 µg 
      100 µg 
      Add to Cart
      반응성: Rat  
      신청: 
        80039-MM12-50
        80039-MM12-200
        80039-MM12-100
        50 µg 
        200 µg 
        100 µg 
        Add to Cart
        반응성: Rat  
        신청: ELISA  WB  IP  
        • Slide 1
        • Slide 1
        80039-T52-50
        80039-T52-200
        80039-T52-100
        50 µg 
        200 µg 
        100 µg 
        Add to Cart
        반응성: Rat  
        신청: ELISA  
          80039-RP01-400
          80039-RP01-200
          80039-RP01-100
          400 µg 
          200 µg 
          100 µg 
          Add to Cart

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          CXCL1 cdna-clone 연구배경

          The Chemokine (C-X-C motif) Ligand 1, CXCL1, is a small cytokine belonging to the CXC chemokine family that was previously called GRO1 oncogene, GRO?, KC, Neutrophil-activating protein 3 (NAP-3) and melanoma growth stimulating activity, alpha (MSGA-a). CXCL1 already known to be important in osteoarthritis (OA), as a novel target gene of transcription factor AP-2? in chondrocytes and support the important role of AP-2? in cartilage. CXCL1 is a potent neutrophil chemoattractant with recognized roles in angiogenesis and inflammation. CXCL1 is a novel immediate PTH/PTHrP-responsive gene. CXCL1 may act as a chemoattractant for osteoclast precursors. CXCL1 may also have important pro-nociceptive effects via its direct actions on sensory neurons, and may induce long-term changes that involve protein synthesis. CXCL1 plays a critical nonredundant role in the development of experimental Lyme arthritis and carditis via CXCR2-mediated recruitment of neutrophils into the site of infection. CXCL1 functions through CXCR2 to transactivate the EGFR by proteolytic cleavage of HB-EGF, leading to activation of MAPK signalling and increased proliferation of epithelial ovarian cancer (EOC) cells. It might limit tumor growth by reinforcing senescence early in tumorigenesis. Thus, CXCL1 plays a role in spinal cord development by inhibiting the migration of oligodendrocyte precursors and is involved in the processes of angiogenesis, inflammation, wound healing, and tumorigenesis.

          휴먼 CXCL1 cdna-clone 참고자료
        • Wang JG, et al. (2008) The chemokine CXCL1/growth related oncogene increases sodium currents and neuronal excitability in small diameter sensory neurons. Mol Pain. 4: 38.
        • Acosta JC, et al. (2009) A role for CXCR2 in senescence, but what about in cancer? Cancer Res. 69(6): 2167-70.
        • Onan D, et al. (2009) The chemokine Cxcl1 is a novel target gene of parathyroid hormone (PTH)/PTH-related protein in committed osteoblasts. Endocrinology. 150(5): 2244-53.
        • Ritzman AM, et al. (2010) The chemokine receptor CXCR2 ligand KC (CXCL1) mediates neutrophil recruitment and is critical for development of experimental Lyme arthritis and carditis. Infect Immun. 78(11): 4593-600.
        • Bolitho C, et al. (2010) The chemokine CXCL1 induces proliferation in epithelial ovarian cancer cells by transactivation of the epidermal growth factor receptor. Endocr Relat Cancer. 17(4): 929-40.
        • Wenke AK, et al. (2011) The transcription factor AP-2? regulates CXCL1 during cartilage development and in osteoarthritis. Osteoarthritis Cartilage. 19(2): 206-12.
        • 주의 : 모든 제품은 "연구 목적만을 위한 것이며 진단이나 치료에 사용하도록 의도되지 않았습니다".