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휴먼 Ephrin-A1/EFNA1 Gene ORF cDNA clone expression plasmid, N-Flag 태그

데이터시트리뷰프로토콜
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10882-H03H-50
10882-H03H-100
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100 µg 
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10882-H08H-50
10882-H08H-5
10882-H08H-100
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5 µg 
100 µg 
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50593-M02H-200
50593-M02H-100
200 µg 
100 µg 
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발현 숙주: Human Cells  
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50593-M08H-50
50593-M08H-5
50593-M08H-100
50 µg 
5 µg 
100 µg 
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제품 설명: Active  
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80115-R08H-500
80115-R08H-200
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200 µg 
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반응성: Human  
신청: ELISA  
    10882-RP01-400
    10882-RP01-200
    10882-RP01-100
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    200 µg 
    100 µg 
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    반응성: Human  
    신청: ELISA  
      10882-MM01-50
      10882-MM01-200
      10882-MM01-100
      10882-MM01-1
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      200 µg 
      100 µg 
      1 mg 
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      반응성: Human  
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        10882-R114-50
        10882-R114-100
        10882-R114-1
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        100 µg 
        1 mg 
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        반응성: Human  
        신청: ELISA  IHC-P  
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        10882-RP02-50
        10882-RP02-200
        10882-RP02-100
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        200 µg 
        100 µg 
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        반응성: Human  
        신청: IHC-P  
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        10882-R453-50
        10882-R453-100
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        100 µg 
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        반응성: Mouse  
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          50593-RP02-50
          50593-RP02-200
          50593-RP02-100
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          200 µg 
          100 µg 
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          반응성: Mouse  
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            50593-RP01-400
            50593-RP01-200
            50593-RP01-100
            400 µg 
            200 µg 
            100 µg 
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            반응성: Rat  
            신청: ELISA  
              80115-RP01-400
              80115-RP01-200
              80115-RP01-100
              400 µg 
              200 µg 
              100 µg 
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              Ephrin-A1/EFNA1 cdna-clone 연구배경

              EPH-related receptor tyrosine kinase ligand 1 (abbreviated as Ephrin-A1) also known as ligand of eph-related kinase 1 or EFNA1, is a member of the ephrin (EPH) family. The Eph family receptor interacting proteins (ephrins) are a family of proteins that serve as the ligands of the Eph receptor, which compose the largest known subfamily of receptor protein-tyrosine kinases (RTKs). Ephrin-A1/EFNA1 and its Eph family of receptor tyrosine kinases are expressed by cells of the SVZ. Ephrin subclasses are further distinguished by their mode of attachment to the plasma membrane: ephrin-A ligands bind EphA receptors and are anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) linkage, whereas ephrin-B ligands bind EphB receptors and are anchored via a transmembrane domain. An exception is the EphA4 receptor, which binds both subclasses of ephrins. Ephrin-A1 and one of its receptor EphA2 were expressed in xenograft endothelial cells and also tumor cells and play a role in human cancers, at least in part by influencing tumor neovascularization.

              휴먼 Ephrin-A1/EFNA1 cdna-clone 참고자료
            • Deroanne C, et al. (2003) EphrinA1 inactivates integrin-mediated vascular smooth muscle cell spreading via the Rac/PAK pathway. J Cell Sci. 116(7): 1367-76.
            • Ojima T, et al. (2006) EphrinA1 inhibits vascular endothelial growth factor-induced intracellular signaling and suppresses retinal neovascularization and blood-retinal barrier breakdown. Am J Pathol. 168(1): 331-9.
            • Wu D, et al. (2004) Prognostic value of EphA2 and EphrinA-1 in squamous cell cervical carcinoma. Gynecol Oncol. 94(2): 312-9.
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