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휴먼 CXCL9 / MIG Gene ORF cDNA clone expression plasmid, N-Flag 태그

데이터시트리뷰프로토콜
발현 숙주: E. coli  
  • Slide 1
10888-HNAE-50
10888-HNAE-20
50 µg 
20 µg 
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발현 숙주: E. coli  
  • Slide 1
50155-MNAE-50
50155-MNAE-20
50 µg 
20 µg 
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반응성: Human  
신청: ELISA  
    10888-R050-50
    10888-R050-100
    10888-R050-1
    50 µg 
    100 µg 
    1 mg 
    Add to Cart
    반응성: Human  
    신청: ELISA  
      10888-RP01-400
      10888-RP01-200
      10888-RP01-100
      400 µg 
      200 µg 
      100 µg 
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      반응성: Human  
      신청: ELISA  
        10888-MM06-50
        10888-MM06-100
        10888-MM06-1
        50 µg 
        100 µg 
        1 mg 
        Add to Cart
        반응성: Human  
        신청: ELISA  WB  
        • Slide 1
        10888-RP02-50
        10888-RP02-200
        10888-RP02-100
        50 µg 
        200 µg 
        100 µg 
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        반응성: Mouse  
        신청: ELISA  
          50155-R277-50
          50155-R277-100
          50 µg 
          100 µg 
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          반응성: Mouse  
          신청: 
            50155-T16-50
            50155-T16-200
            50155-T16-100
            50 µg 
            200 µg 
            100 µg 
            Add to Cart
            반응성: Mouse  
            신청: ELISA  
              50155-RP02-50
              50155-RP02-200
              50155-RP02-100
              50 µg 
              200 µg 
              100 µg 
              Add to Cart
              반응성: Mouse  
              신청: ELISA  IHC-P  
              • Slide 1
              • Slide 1
              • Slide 1
              • Slide 1
              50086-R008-50
              50086-R008-100
              50 µg 
              100 µg 
              Add to Cart
              반응성: Cynomolgus  
              신청: ELISA  
                90014-R046-50
                90014-R046-100
                50 µg 
                100 µg 
                Add to Cart
                반응성: Rhesus  
                신청: ELISA  
                  90135-RP01-400
                  90135-RP01-200
                  90135-RP01-100
                  400 µg 
                  200 µg 
                  100 µg 
                  Add to Cart
                  반응성: Rhesus  
                  신청: ELISA  
                    90135-T16-50
                    90135-T16-200
                    90135-T16-100
                    50 µg 
                    200 µg 
                    100 µg 
                    Add to Cart

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                    CXCL9 / MIG cdna-clone 연구배경

                    Chemokine (C-X-C motif) ligand 9 (CXCL9), also known as Monokine induced by gamma interferon (MIG), is a small cytokine belonging to the CXC chemokine family. The function of this chemokine has not been specifically defined; however, it is thought to be involved in T cell trafficking. CXCL9/MIG functions as one of the three ligands of chemokine receptor CXCR3 which is a G protein-coupled receptor found predominantly on T cells. CXCL9/MIG, together with CXCL10 and CXCL11, may activate CXCR3 by binding to it. CXCL9 serves as a cytokine that affects the growth, movement, or activation state of cells that participate in immune and inflammatory response. It has been observed that tumour endothelial cells secrete high levels of CXCL9 in all, and CXCL10 in most melanoma metastases. Experiment data represent novel mechanisms by which tumour cells in melanoma metastases might use the chemokine-expressing endothelium to leave the tumour and eventually to form additional metastases at distinct sites. Experiment results also improved that CXCL9/MIG plays an important role in CD4+ T lymphocyte recruitment and development of CAV, MOMA-2+ macrophages are the predominant recipient-derived source of CXCL9/MIG, and recipient CD4 lymphocytes are necessary for sustained CXCL9/MIG production and CAV development in this model. Neutralization of the chemokine CXCL9/MIG may have therapeutic potential for the treatment of chronic rejection after heart transplantation.

                    휴먼 CXCL9 / MIG cdna-clone 참고자료
                  • Ruehlmann JM, et al. (2001) MIG (CXCL9) chemokine gene therapy combines with antibody-cytokine fusion protein to suppress growth and dissemination of murine colon carcinoma. Cancer Res. 61(23): 8498-503.
                  • Belperio JA, et al. (2003) Role of CXCL9/CXCR3 chemokine biology during pathogenesis of acute lung allograft rejection. J Immunol. 171(9): 4844-52.
                  • Colvin RA, et al. (2004) Intracellular domains of CXCR3 that mediate CXCL9, CXCL10, and CXCL11 function. J Biol Chem. 279(29): 30219-27.
                  • Valbuena G, et al. (2003) Expression analysis of the T-cell-targeting chemokines CXCL9 and CXCL10 in mice and humans with endothelial infections caused by rickettsiae of the spotted fever group. Am J Pathol. 163(4): 1357-69.
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