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휴먼 BMF / Bcl2 modifying factor Gene ORF cDNA clone expression plasmid, C-Flag 태그

데이터시트리뷰프로토콜
반응성: Human  
신청: ELISA  
    13639-T16-50
    13639-T16-200
    13639-T16-100
    50 µg 
    200 µg 
    100 µg 
    Add to Cart
    반응성: Human  
    신청: ELISA  
      13639-RP01-400
      13639-RP01-200
      13639-RP01-100
      400 µg 
      200 µg 
      100 µg 
      Add to Cart

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      BMF / Bcl2 modifying factor cdna-clone 연구배경

      BMF(Bcl2 modifying factor) belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. BMF contains a single BCL2 homology domain 3 (BH3), and has been shown to bind BCL2 proteins and function as an apoptotic activator. BMF is found to be sequestered to myosin V motors by its association with dynein light chain 2, which may be important for sensing intracellular damage and triggering apoptosis. Alternatively spliced transcript variants encoding different isoforms have been identified.

      휴먼 BMF / Bcl2 modifying factor cdna-clone 참고자료
    • Hattori A, et al. (2001) Characterization of long cDNA clones from human adult spleen. DNA Res. 7(6):357-66.
    • Day Catherine L, et al. (2004) Localization of dynein light chains 1 and 2 and their pro-apoptotic ligands. Biochem J. 377(Pt 3):597-605.
    • Puthalakath H, et al. (2001) Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis. Science. 293(5536):1829-32.
    • 주의 : 모든 제품은 "연구 목적만을 위한 것이며 진단이나 치료에 사용하도록 의도되지 않았습니다".