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휴먼 GITR/TNFRSF18/CD357 Gene ORF cDNA clone expression plasmid, C-Flag 태그

데이터시트리뷰프로토콜
발현 숙주: Human Cells  
  • Slide 1
13643-H08H-20
13643-H08H-100
20 µg 
100 µg 
Add to Cart
발현 숙주: Human Cells  
  • Slide 1
13643-H02H-50
13643-H02H-100
50 µg 
100 µg 
Add to Cart
발현 숙주: Human Cells  
  • Slide 1
80192-R02H-50
80192-R02H-100
50 µg 
100 µg 
Add to Cart
반응성: Human  
신청: ELISA  
    13643-RP01-400
    13643-RP01-200
    13643-RP01-100
    400 µg 
    200 µg 
    100 µg 
    Add to Cart
    반응성: Human  
    신청: ELISA  
      13643-T16-50
      13643-T16-200
      13643-T16-100
      50 µg 
      200 µg 
      100 µg 
      Add to Cart

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      GITR/TNFRSF18/CD357 cdna-clone 연구배경

      GITR, also known as TNFRSF18(CD357), belongs to the tumor necrosis factor receptor (TNF-R) superfamily. It is the receptor for TNFSF18. GITR plays a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. GITR may be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. GITR and its ligand are important costimulatory molecules in the pathogenesis of autoimmune diseases. It also mediates NF-kappa-B activation via the TRAF2/NIK pathway.

      Immune Checkpoint
      Immune Checkpoint Detection: ELISA Antibodies
      Immune Checkpoint Targets   Co-stimulatory Immune Checkpoint Targets

      Immunotherapy   Cancer Immunotherapy   Targeted Therapy

      휴먼 GITR/TNFRSF18/CD357 cdna-clone 참고자료
    • Kwon B, et al. (1999) Identification of a novel activation-inducible protein of the tumor necrosis factor receptor superfamily and its ligand. J Biol Chem. 274(10):6056-61.
    • Nocentini G, et al. (1997) A new member of the tumor necrosis factor/nerve growth factor receptor family inhibits T cell receptor-induced apoptosis. Proc Natl Acad Sci. 94(12): 6216-21.
    • Baltz KM, et al. (2007) Cancer immunoediting by GITR (glucocorticoid-induced TNF-related protein) ligand in humans: NK cell/tumor cell interactions. FASEB J. 21(10):2442-54.
    • 주의 : 모든 제품은 "연구 목적만을 위한 것이며 진단이나 치료에 사용하도록 의도되지 않았습니다".