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Fc receptor

Fc receptor is a protein belonging to immunoglobulin superfamily that contributes to the protective functions of the immune system. Fc receptor is found on the surface of certain cells - including B lymphocytes, natural killer cells, macrophages, neutrophils and mast cells. Its name is derived from its binding specificity for a part of an antibody known as the Fc portion. Fc receptors bind to antibodies that are attached to infected cells or invading pathogens. There are many kinds of Fc receptors based on the type of antibody that they recognize. Their activity stimulates phagocytic or cytotoxic cells to destroy microbes or infected cells by antibody-mediated phagocytosis or antibody-dependent cell-mediated cytotoxicity.

Function of Fc receptors:

1. Involved in innate & adaptive immune system
2. Activation of phagocytes
3. Involved in antibody-dependent cell-mediated cytotoxicity (ADCC)
4. Stimulate NK cells to release cytotoxic molecules
5. Involved in allergic reactions
6. Defense against parasitic infections.

Application of Fc receptors:

1. ADCC activity evaluation of therapeutic monoclonal antibody
2. Indicator of allergic reaction test
3. PK/PD analysis of therapeutic monoclonal antibody
4. Drug targets of potential autoimmune disease

Fc receptor Types & Molecules

 Fc Receptor binding IgA

 Fc Receptor binding IgE

 Fc Receptor-Like molecule / FCRL

 Fc Receptor binding IgG
CD16 / FCGR3
CD32a / FCGR2A

 Fc Receptor binding IgA & IgM

Fc receptor reagent advantages

Fc Receptor binding IgA

  • High purity: >95%
  • Mutiple species
  • Low endotoxin: <1.0 EU/μg
  • High Binding activity

 FCGR2A/CD32a protein
FCGR2A / CD32a (10374-H08B)
binds to recombinant human IgG1

 FCGRT & B2M protein
FCGRT & B2M (CT009-H08H)
binds to recombinant human IgG1

 FCGR2B / CD32b protein
FCGR2B / CD32b (10259-H08H)
binds to recombinant human IgG1

Fc receptor Antibody

  • Multiple applications
  • High affinity & sensitivity
  • Multiple antibody types

 FCGR1/CD64 IHC antibody
Detection of FCGR1 / CD64 in mouse liver by immunohistochemistry (50086-R008)

 FCGR4 / CD16-2 IF antibody
Detectionof Mouse FCGR4 / CD16-2 in RAW264.7 cells by immunofluorescence (50036-R012)

 FCAR / CD89 FCM antibody
Flow cytometric analysis of anti-human FCAR / CD89 antibody on human whole blood monocytes (10414-MM02-P)

Fc receptor Gene

  • Multiple applications
  • High affinity & sensitivity
  • Multiple antibody types

 FMultiple species
Covering 5 species including Human, Mouse, Rat, Rabbit, Cynomolgus

 Validated expression
Enhanced promoter, full sequence validated,

 Mutiple tags
GFP, OFP, Myc, His, Flag, HA, untagged

Fc receptor ELISA Kit

  • High specificity & stability
  • Low detection limit: 3.1 pg/ml

 Cynomolgus CD16 ELISA Pair Set
Cynomolgus CD16 ELISA Pair Set Standard Curve (SEK90013)

 Human CD32b ELISA Pair Set
Human CD32b / FCGR2B ELISA Pair Set Standard Curve (SEKA10259)

 Human CD89/FCAR ELISA Pair Set
Human CD89/FCAR ELISA Pair Set Standard Curve (SEK10414)

Fc receptor informations