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Receptors

Receptors classification

what are Receptors

Cytokine Receptors

Fc Receptor / FcR

Growth Factor Receptors

Receptors by Differentiation Cells

 

Receptors by Drug Target

Most popular GPCRs as Drug target

ACKR3 ADORA1 ADORA2A ADORA2B
ADORA3 ADRA1A ADRA1B ADRA2A
ADRB2 AGTR1 AGTR2 AVPR1A
AVPR2 BDKRB1 BDKRB2 C5AR1
C5AR2 CALCR CCR1 CCR2
CCR4 CCR5 CCR6 CCR9
CHRM2 CHRM4 CHRM5 CNR1
CX3CR1 CXCR4 CXCR5 CYSLTR1
DRD1 DRD2 DRD5 EDNRA
EDNRB F2R F2RL1 F2RL3
FFAR1 FSHR FZD1 FZD10
FZD2 FZD3 FZD4 FZD5
FZD6 FZD9 GLP1R GLP2R
GPR180 GPR6 GRM2 HCRTR2
HTR2A HTR2B HTR4 HTR5A
HTR6 OPRD1 OPRK1 P2RY12
P2RY2 PTAFR PTGER1 PTGIR
PTH1R RXFP2 S1PR1 SSTR2
TACR2 TBXA2R TSHR VIPR1
VIPR2      

Receptor Tyrosine Kinases/RTKs as Drug Target

AXL CSF1R DDR1 DDR2
EPHA1 EPHA2 EPHA3 EPHA4
EPHA6 EPHA7 EPHA8 EPHB1
EPHB2 EPHB3 EPHB4 EPHB6
EGFR ERBB2 ERBB3 ERBB4
FGFR1 FGFR2 FGFR3 FGFR4
FLT1 FLT3 FLT4 IGF1R
INSR KDR KIT LTK
MST1R MUSK NTRK1 NTRK2
NTRK3 PDGFRA PDGFRB RET
ROR1 ROR2 RYK TEK
TIE1      

Receptor Serine/Threonine Kinases as Drug Target

ADRBK1 ADRBK2 ACVR1 ACVR1B
ACVR1C ACVR2A ACVR2B ACVRL1
BMPR1A BMPR1B BMPR2 GRK1
GRK4 GRK5 GRK6 RIPK1
RIPK2 RIPK3 RIPK4 TGFBR1
TGFBR2 AMHR2    

Nuclear Hormone Receptors/NHRs as Drug Target

THRB RARA RARB RARG
PPARA PPARG NR1D1 NR1D2
RORA RORB RORC NR1H4
NR1H3 NR1H2 VDR NR1I2
NR1I3 HNF4A HNF4G RXRA
RXRB RXRG NR2C2 NR2F2
NR2F6 ESR1 ESR2 ESRRA
ESRRB AR NR3C1 NR3C2
PGR NR4A1 NR4A2 NR5A1
NR6A1 NR0B1 NR0B2  

Host Defense Receptors as Drug Target

BST1 BST2 CD3E CD3D
CD3G CD36 PLAUR PVR
CD200R1 CD200R1L PROCR CD244
CR1 CR1L CR2 CFHR1
CFHR2 CFHR5 FCGR2A FCGR2B
FCGR3A FCGR3B FCGRT FCAMR
FCAR FCER1A MS4A2 FCER1G
FCER2 FCRL1 FCRL2 FCRL3
FCRL4 FCRL5 FCRL6 FCRLA
ICOS KIR2DL1 KIR2DL3 KIR2DL4
KIR2DL5A KIR2DL5B KIR3DL1 KIR3DL3
KIR3DS1 KLRC1 KLRC2 KLRC3
KLRD1 KLRF1 KLRG1 KLRK1
LAIR1 LAIR2 LILRA1 LILRA2
LILRA3 LILRA4 LILRA5 LILRB1
LILRB2 LILRB3 LILRB4 LILRB5
NCR1 NCR2 NCR3 NCR3LG1
TLR1 TLR2 TLR3 TLR4
TLR5 TLR6 TLR7 TLR8
TLR9 TLR10 TREM1 TREM2
TREML1 TREML2 TREML4 MARCO
MILR1 PLGRKT PIGR TIGIT

Cell Adhesion Receptors as Drug Target

ASGR1 ASGR2 PEAR1 F11R
AGER SELL PVRL1 PVRL2
PVRL3 PVRL4 MRC1 ITGAM
ITGB2 ITGAX ITGB1 ITGA2
ITGA3 ITGA4 ITGA5  

Other Receptors as Drug Target

CHRNA3 CHRNA5 CHRNA7 CHRNB3
CHRNG GABRA1 GABRA3 GABRA4
GABRB1 GABRB2 GABRB3 GABRD
GABRE GABRG1 GABRP GABRR1
GABRR2 GABRQ GRIA1 GRIA2
GRIA3 GRID2 GRIK2 GLRA2
GLRA3 GLRB P2RX1 P2RX2
TRPC3 TRPC4 TRPC7 TRPV2
FLVCR1 FLVCR2 LDLR LRP1
LRP8 VLDLR SCARA5 SCARB1
SCARB2 MSR1 TFRC TFR2

Receptors Reagent Products

Receptors ELISA kits

Anti-Receptors antibody

Receptors cDNA clones

Receptors recombinant protein

Receptors by Species

Human Receptor

Mouse Receptor

Cytokine & Growth Factor Receptors

Tie Receptor EGF Receptor
Eph Receptor PDGF Receptor
TNF Receptor Interleukin Receptor
Wnt Receptor Chemokine Receptor
CSF Receptor Interferon/IFN Receptor
IGF Receptor Neurotrophin Receptor
FGF Receptor TGF-beta Superfamily Receptor
VEGF Receptor  

Interleukin & Interleukin Receptor

IL-1A

IL-1R1
IL-1R2
IL-1RAcP
 

IL-1B

IL-1R1
IL-1R2
IL-1RAcP
 

IL-1RA

IL-1R1
IL-1R2

 

IL-2

IL-2Rα
IL-2Rβ
IL-2Rγ
 

IL-3

IL-3Rα
CSF2RB

 

IL-4

IL-4R
IL-2Rγ
IL-13Rα1
 

IL-5

IL-5Rα
CSF2RB

 

IL-6

IL-6Rα
gp130

 

IL-7

IL-7Rα
IL-2Rγ

 

IL-8/CXCL8

CXCR1
CXCR2

 

IL-9

IL-9R
IL-2Rγ

 

IL-10

IL-10Rα
IL-10Rβ

 

IL-11

IL-11Rα
gp130

 

IL-12A

IL-12Rβ1
IL-12Rβ2

 

IL-12B

IL-12Rβ1
IL-12Rβ2

 

IL-13

IL-13Rα1
IL-13Rα2
IL-4R
 

IL-14/TXLNA

unknown


 

IL-15

IL-15Rα
IL-2Rβ
IL-2Rγ
 

IL-16

CD4
CD9

 

IL-17A

IL-17RA
IL-17RC
IL-17RD
 

IL-17B

IL-17RB


 

IL-17C

IL-17RA
IL-17RE

 

IL-17D

unknown


 

IL-17F

IL-17RA
IL-17RC

 

IL-18

IL-18Rα
IL-18RAcP
IL18BP / IL18BPa

 

IL-19

IL-20Rα
IL-20Rβ

 

IL-20

IL-20Rα
IL-20Rβ
IL-22Rα1
 

IL-21

IL-21R
IL-2Rγ

 
 

IL-22

IL-22Rα1
IL-22Rα2
IL-10Rβ
 

IL-23

IL-12Rβ1
IL-23R

 

IL-24

IL-20Rα
IL-20Rβ
IL-22Rα1
 

IL-25/IL-17E

IL-17RA
IL-17RB

 
 

IL-26

IL-10Rβ
IL-20Rα

 

IL-27/IL-30

IL-27Rα
gp130

 

IL-28A

IL-28RA
IL-10Rβ

 

IL-28B

IL-28RA
IL-10Rβ

 
 

IL-29

IL-28RA
IL-10Rβ

 

IL-31

IL-31Rα
OSMR

 

IL-32

PR3     STAT3
PKCε     Paxillin
PKCδ
 

IL-33

IL-1R1
IL-1R2
IL-1RAcP
 
 

IL-34

IL-1R1
IL-1R2
IL-1RAcP
 

IL-35

IL-12Rβ2
gp130

 

IL-36A

IL-1RL2
IL-1RAcP

 

IL-36B

IL-1RL2
IL-1RAcP

 
 

IL-36G

IL-1RL2
IL-1RAcP

 

IL-36RA

IL-1RL2
IL-1RAcP

 

IL-37

IL18R1
IL18BP / IL18BPa


 

IL-38/IL1F10

IL1R1/IL-1R1
IL1RL2/IL1RRP2


 

TNF & TNF Receptor

TNFRSF1A

TNF-alpha


 

TNFRSF1B

TNF-alpha


 

LTBR

TNF-C


 

TNFRSF4

OX40L


 

CD40

CD154


 

TNFRSF6B

FasL
LIGHT
TL1A
 

CD27

CD70
Siva

 

TNFRSF8

CD153


 

TNFRSF9

4-1BB ligand


 

TNFRSF10A

TRAIL


 

TNFRSF10C

TRAIL


 

TNFRSF10C

TRAIL


 

TNFRSF10D

TRAIL


 

TNFRSF11A

RANKL


 

TNFRSF11B

RANKL


 

TNFRSF12A

TWEAK


 

TNFRSF13B

APRIL
BAFF
CAMLG
 

TNFRSF13C

BAFF


 

TNFRSF14

LIGHT


 

NGFR

NGF
BDNF
NT-3     NT-4
 

TNFRSF17

BAFF


 

TNFRSF18

GITR ligand


 

TNFRSF19

unknown


 

FAS

TNF-alpha
BAFF-R
BCMA     TACI
 

TNFRSF21

unknown


 

TNFRSF25

TL1A


 

EDA2R

EDA-A2


   

Chemokine & Chemokine Receptor

CCL1

CCR8


 

CCL2

CCR2


 

CCL3

CCR1


 

CCL4

CCR1
CCR5

 

CCL5

CCR5


 

CCL6

CCR1


 

CCL7

CCR2


 

CCL8

CCR1
CCR2
CCR5
 

CCL9

CCR1


 

CCL11

CCR2
CCR3
CCR5
 

CCL12

CXCR4


 

CCL13

CCR2
CCR3
CCR5
 

CCL14

CCR1


 

CCL15

CCR2
CCR5

 

CCL16

CCR1
CCR2
CCR5     CCR8
 

CCL17

CCR4


 

CCL18

CCR8
DARC
PITPNM3     GPR30
 

CCL19

CCR7


 

CCL20

CCR6


 

CCL21

CCR7


 

CCL22

CCR4


 

CCL23

CCR1


 

CCL24

CCR3


 

CCL25

CCR9


 

CCL26

CCR3


 

CCL27

CCR9


 

CCL28

CCR3
CCR10

 

CXCL1

CXCR2


 

CXCL2

CXCR2


 

CXCL3

CXCR2


 

CXCL4

CXCR3


 

CXCL5

CXCR2


 

CXCL6

CXCR1
CXCR2

 

CXCL7

CXCR2


 

CXCL8

CXCR1
CXCR2

 

CXCL9

CXCR3


 

CXCL10

CXCR3


 

CXCL11

CXCR3
CXCR7

 

CXCL12

CXCR4
CXCR7

 

CXCL13

CXCR5


 

CXCL14

CXCR4


 

CXCL15

unknown


 

CXCL16

CXCR6


 

CXCL17

CXCR8


 

XCL1

XCR1


 

XCL2

XCR1


 

CX3CL1

CX3CR1


   

Receptors by Differentiation Cells Back to Top

B Cell Receptor Dendritic Cell Receptor Granulocyte Receptor Monocyte Receptor
Stem Cell Receptor T Cell Receptor NK Cell Receptor  

Receptors by Functions Back to Top

Receptors Related to Innate Immunity Receptors Related to CD Antigens Receptors Related to Cell Activation
Receptors Related to Signaling Pathways Receptors Related to Cell Adhesion  

Receptors Background Back to Top

Receptors are proteins, usually cell surface receptors, which bind to ligands and cause responses in the immune system. Receptors can be found in various immune cells like B cells, T cells, NK cells, monocytes and stem cells. Receptors allow the cells to recognize specific ligands and to receive extracellular messages. They can be classified into five families: 1) receptors for lipidic or lipophilic ligands; 2) the seven transmembrane receptors which mediate their messages by transduction through the activation of G-proteins, effectors and second messengers to amplify the response; 3) receptors which present an enzymatic activity on their transmembrane domains; 4) channel-receptors, transmembrane oligomeric molecules which let ions flow into the cell and 5) receptors which role is to internalize ligands, whatever their various functions.

In addition, receptors play a critical role in functions such as cell activation, cell adhesion and signaling pathways. For example, cell activation including T cells, dendritic cells, B cells, granulocytes and NK cells, is an important process in innate and adaptive immune system. Receptors on the surface of these cells help complete whole cell activation process. The innate immunity receptors that recognize pathogens also have an important role in signaling for the induced responses responsible for local inflammation, the recruitment of new effector cells, the containment of local infection, and the initiation of an adaptive immune response.

Receptors References Back to Top

1. Feger, J., Gil-Falgon, S., & Lamaze, C. (1994). Cell receptors: definition, mechanisms and regulation of receptor-mediated endocytosis. Cellular and molecular biology (Noisy-le-Grand, France), 40(8), 1039-1061.

2. Akira, S., Uematsu, S., & Takeuchi, O. (2006). Pathogen recognition and innate immunity. Cell, 124(4), 783-801.

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