ULBP2 (Protein | Antibody | cDNA Clone | ELISA Kit)

All ULBP2 reagents are produced in house and quality controlled, including 5 ULBP2 Antibody, 13 ULBP2 Gene, 2 ULBP2 Lysate, 3 ULBP2 Protein, 1 ULBP2 qPCR. All ULBP2 reagents are ready to use.

ULBP2 Protein (3)

    ULBP2 Antibody (5)

      ULBP2 cDNA Clone (13)

      BC034689

      ULBP2 qPCR Primer (1)

      ULBP2 Lysate (2)

        ULBP2 Background

        NKG2D ligand 2, also known as N2DL-2, NKG2DL2, ALCAN-alpha, Retinoic acid early transcript 1H, UL16-binding protein 2, ULBP2 and N2DL2, is cell membrane protein which belongs to theMHC class I family. ULBP2 / N2DL-2 is expressed in various types of cancer cell lines and in the fetus, but not in normal tissues. ULBP2 / N2DL-2 is a ligand for the NKG2D receptor, together with at least ULBP1 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway.

        ULBP2 References

        • Cosman D. et al., 2001,Immunity 14:123-133
        • Cerwenka A., et al., 2003, Tissue Antigens 61:335-343
        • Chang,Y.T. et al., 2011, PLoS One. 6 (5):e20029