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YWHAQ

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YWHAQ 요약 및 단백질 정보

YWHAQ 배경

유전자 요약: This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse and rat orthologs. This gene is upregulated in patients with amyotrophic lateral sclerosis. It contains in its 5' UTR a 6 bp tandem repeat sequence which is polymorphic, however, there is no correlation between the repeat number and the disease.
General information above from NCBI
하부단위 구조: Homodimer. Interacts with CDK16 (By similarity). Interacts with SSH1. Interacts with CDKN1B ('Thr-198' phosphorylated form); the interaction translocates CDKN1B to the cytoplasm. Interacts with GAB2. Interacts with the 'Ser-241' phosphorylated form of PDPK1. {ECO:0000250, ECO:0000269|PubMed:12042314, ECO:0000269|PubMed:12177059, ECO:0000269|PubMed:15159416, ECO:0000269|PubMed:17085597, ECO:0000269|PubMed:19172738}.
세포하 위치: Cytoplasm. Note=In neurons, axonally transported to the nerve terminals.
조직 특이성: Abundantly expressed in brain, heart and pancreas, and at lower levels in kidney and placenta. Up-regulated in the lumbar spinal cord from patients with sporadic amyotrophic lateral sclerosis (ALS) compared with controls, with highest levels of expression in individuals with predominant lower motor neuron involvement. {ECO:0000269|PubMed:11080204}.
번역 후: Ser-232 is probably phosphorylated by CK1. {ECO:0000269|PubMed:9360956}.
염기서열 유사성: Belongs to the 14-3-3 family. {ECO:0000305}.
General information above from UniProt

YWHAQ 대체 이름

HS1,1C5,41701, [homo-sapiens]
14-3-3 tau,1C5,HS1,14-3-3 theta,YWHAQ, [human]
14-3-3 tau,MGC118161,R74690,14-3-3 theta,2700028P07Rik,AA409740,AU021156,Ywhaq, [mouse]
R74690,AA409740,AU021156,2700028P07Rik, [mus-musculus]

YWHAQ 관련 연구

  • Cheng Y, et al. (2010) Effect of 14-3-3 tau protein on differentiation in BeWo choriocarcinoma cells. Placenta. 31(1): 60-6.
  • Umahara T, et al. (2010) 14-3-3 proteins and spinocerebellar ataxia type 1: from molecular interaction to human neuropathology. Cerebellum. 9(2): 183-9.
  • Wang B, et al. (2004) A role for 14-3-3 tau in E2F1 stabilization and DNA damage-induced apoptosis. J Biol Chem. 279(52): 54140-52.
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