All 2B4 / CD244 reagents are produced in house and quality controlled, including 6 2B4 / CD244 Antibody, 1 2B4 / CD244 ELISA, 13 2B4 / CD244 Gene, 1 2B4 / CD244 IPKit, 2 2B4 / CD244 Lysate, 2 2B4 / CD244 Protein, 1 2B4 / CD244 qPCR. All 2B4 / CD244 reagents are ready to use.
Recombinant 2B4 / CD244 proteins are expressed by HEK293 Cells with fusion tags as C-human IgG1-Fc, C-His.
2B4 / CD244antibodies are validated with different applications, which are WB, ELISA(Cap), IP, ELISA, FCM, ELISA(Det).
2B4 / CD244cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each 2B4 / CD244 of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
2B4 / CD244ELISA Kit are quality controlled by 8 internation QC standard which guarantee every ELISA Kit with high quality.
The CD244 antigen, also known as 2B4, is a cell surface glycoprotein implicated in the regulation of natural killer and T lymphocyte function. 2B4 is a member of the signaling lymphocyte activation molecule (SLAM)-related receptor family and is important for stimulating NK cell cytotoxicity and cytokine production, which is expressed on all NK cells, a subpopulation of T cells, monocytes and basophils. The 2B4 antigen identified on NK cells and T cells is capable of transmitting stimulatory signals and non-MHC-restricted killing. Reported as an activating receptor, human 2B4 can effectively activate and enhance NK cell–mediated cytotoxicity, induce secretion of IFN-γ and matrix metalloproteinases (MMPs), as well as NK cell invasiveness. As a cell surface glycoprotein of the Ig-superfamily structurally related to CD2-like molecules such as CD2, CD48, CD58, CD84, Ly-9, and SLAM, 2B4 (CD244) is expressed on all human NK cells, a subpopulation of T cells, basophils and monocytes. 2B4 activates NK cell mediated cytotoxicity, induces secretion of IFN-gamma and matrix metalloproteinases, and NK cell invasiveness.
Immune Checkpoint Detection: Antibodies Immune Checkpoint Detection: ELISA Antibodies Immune Checkpoint Detection: IP Antibodies Immune Checkpoint Detection: FCM Antibodies
Immune Checkpoint Proteins
Immune Checkpoint Targets Co-inhibitory Immune Checkpoint Targets