4-1BBL: 4-1BBL protein | 4-1BBL antibody

4-1BBL General information

APPROVED SYMBOL
 TNFSF9
APPROVED NAME
 TNF superfamily member 9
HGNC ID
 HGNC:11939
SYNONYMS
 4-1BB-L, homolog of mouse 4-1BB-L, receptor 4-1BB ligand
LOCUS TYPE
 gene with protein product
CHROMOSOMAL LOCATION
 19p13.3
HCOP
Orthology Predictions for TNFSF9 From HGNC

From HGNC

4-1BBL Gene family protein & antibody (Tumor necrosis factor superfamily)

Approved Symbol
Common name
Reagent list
CD40LG
CD40LG
FASLG
FASLG
LTB
LTB
TNFSF10
TNFSF10
TNFSF12
TNFSF12
TNFSF13B
TNFSF13B
TNFSF15
TNFSF15
TNFSF4
TNFSF4
Approved Symbol
Common name
Reagent list
CD70
CD70
LTA
LTA
TNF
TNF
TNFSF11
TNFSF11
TNFSF13
TNFSF13
TNFSF14
TNFSF14
TNFSF18
TNFSF18
TNFSF8
TNFSF8

4-1BBL Gene family members (Tumor necrosis factor superfamily)

Approved Symbol
Approved Name
Synonyms
CD40LG
CD154, CD40 antigen ligand, CD40L, gp39, hCD40L, hyper-IgM syndrome, T-B cell-activating molecule, TNF-related activation protein, TRAP, tumor necrosis factor (ligand) superfamily member 5
CD70
CD27L
FASLG
CD178, FasL
LTA
LT, TNF superfamily member 1, TNFSF1
LTB
p33, TNF superfamily member 3, TNFSF3
TNF
DIF, TNF superfamily, member 2, TNF-alpha, TNFSF2
TNFSF10
Apo-2L, CD253, TL2, TRAIL
TNFSF11
CD254, ODF, OPGL, RANKL, TRANCE
TNFSF12
APO3L, DR3LG, TWEAK
TNFSF13
APRIL, CD256
TNFSF13B
BAFF, BLYS, CD257, TALL1, TALL-1, THANK
TNFSF14
CD258, HVEM-L, LIGHT, LTg
TNFSF15
MGC129934, MGC129935, TL1, TL1A, TNF ligand-related molecule 1, TNF superfamily ligand TL1A, vascular endothelial cell growth inhibitor, vascular endothelial growth inhibitor-192A, VEGI, VEGI192A
TNFSF18
AITRL, hGITRL, TL6
TNFSF4
CD252, gp34, OX-40L
TNFSF8
CD153

4-1BBL background

4-1BBL is the high affinity ligand of 4-1BB, also known as CD137L or TNFSF9. It is shown to be a type II surface glycoprotein belonging to the TNF superfamily. Expression of 4-1BBL is restricted to APCs, such as dendritic cells, macrophages, and activated B cells. Members of the TNF-TNF receptor superfamily have been shown to play critical roles in regulating cellular activation, differentiation and apoptosis. Several studies have reported that 4-1BBL/4-1BB interaction provided a co-stimulatory signal to T cells, and increased T cell proliferation and cytokines production. In additon, 4-1BBL is involved in cancers, infectious diseases and autoimmune diseases.<a href="/immune-checkpoint.html">Immune Checkpoint</a><br><a href="/immune-checkpoint-detection-antibodies.html">Immune Checkpoint Detection: Antibodies</a>&nbsp;&nbsp;&nbsp;<a href="/immune-checkpoint-detection-elisa-antibodies.html">Immune Checkpoint Detection: ELISA Antibodies</a>&nbsp;&nbsp;&nbsp;<a href="/immune-checkpoint-detection-icc-antibodies.html">Immune Checkpoint Detection: ICC Antibodies</a>&nbsp;&nbsp;&nbsp;<a href="/immune-checkpoint-detection-fcm-antibodies.html">Immune Checkpoint Detection: FCM Antibodies</a><br><a href="/immune-checkpoint-targets.html">Immune Checkpoint Targets</a>&nbsp;&nbsp;&nbsp;<a href="/co-stimulatory-immune-checkpoint-targets.html">Co-stimulatory Immune Checkpoint Targets</a> <a href="/immunotherapy.html">Immunotherapy</a>&nbsp;&nbsp;&nbsp;<a href="/cancer-immunotherapy.html">Cancer Immunotherapy</a>&nbsp;&nbsp;&nbsp;<a href="/targeted-therapy.html">Targeted Therapy</a>

Reference for 4-1BBL

• Cheung CT, (2007) Neutralizing anti-4-1BBL treatment improves cardiac function in viral myocarditis. Lab Invest. 87(7): 651-61.

• Wang C, et al. (2009) Immune regulation by 4-1BB and 4-1BBL: complexities and challenges. Immunol Rev. 229(1): 192-215.

• Habib-Agahi M, et al. (2009) 4-1BBL costimulation retrieves CD28 expression in activated T cells. Cell Immunol. 256(1-2): 39-46.

4-1BBL Protein

4-1BBL protein function

Cytokine that binds to TNFRSF9. Induces the proliferation of activated peripheral blood T-cells. May have a role in activation-induced cell death (AICD). May play a role in cognate interactions between T-cells and B-cells/macrophages. {ECO:0000269|PubMed:20032458}.

4-1BBL protein expression

Tissue specificity

Expressed in brain, placenta, lung, skeletal muscle and kidney.


4-1BBL protein sequence

Length: 254.00

Mass (Da): 26.00

This sequence information is just for reference only.From Uniport

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4-1BBL Gene

The protein encoded by this gene is a protease inhibitor and cytokine transporter. It uses a bait-and-trap mechanism to inhibit a broad spectrum of proteases, including trypsin, thrombin and collagenase. It can also inhibit inflammatory cytokines, and it thus disrupts inflammatory cascades. Mutations in this gene are a cause of alpha-2-macroglobulin deficiency. This gene is implicated in Alzheimer's disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. A related pseudogene, which is also located on the p arm of chromosome 12, has been identified. [NCBI]

Learn more about 4-1BBL gene information & reagent