Anti-Nectin-2 Antibody

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Anti-Nectin-2 Antibody (Rabbit Monoclonal antibody) General Information

Product name
Anti-Nectin-2 Antibody
Validated applications
ELISA(Cap),FCM
Species reactivity
Reacts with: Human
Specificity
Human Nectin-2
No cross-reactivity in ELISA with
Mouse PVRL2
Immunogen
Recombinant Human CD112 protein (Catalog#10005-H08H)
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Human CD112 extracellular domain (rh CD112; Catalog#10005-H08H; Met 1-Leu 360; NP_002847.1).
Source
Monoclonal Rabbit IgG Clone #005
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-Nectin-2 Antibody (Rabbit Monoclonal antibody) Validated Applications

Application Dilution
FCM 1:25-1:100
ELISA(Cap) 1:250-1:2000
Notes
ELISA(Cap): This antibody will detect Human CD112 / Nectin-2 / PVRL2 in ELISA pair set (Catalog: # SEK10005). In a sandwich ELISA, it can be used as capture antibody.
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-Nectin-2 Antibody (Rabbit Monoclonal antibody) Images

Flow cytometric analysis of anti-Human PVRL2(CD112) on HL60 cells

Anti-Nectin-2 Antibody: Alternative Names

Anti-CD112 Antibody; Anti-HVEB Antibody; Anti-Nectin-2 Antibody; Anti-PRR2 Antibody; Anti-PVRR2 Antibody

Nectin-2 Background Information

Cluster of Differentiation 112 (CD112), also known as poliovirus receptor related protein 2 (PVRL2 or PRR2), is a single-pass type I transmembrane glycoprotein belonging to the Immunoglobulin superfamily. CD112 protein also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and thus is involved in cell to cell spreading of these viruses. CD112 protein has been identified as the ligand for DNAM-1 (CD226), and the interaction of CD226/CD112 protein can induce NK cell- and CD8+ T cell-mediated cytotoxicity and cytokine secretion. CD112 has been regarded as a critical component in allergic reactions, and accordingly may function as a novel target for anti-allergic therapy.
Full Name
poliovirus receptor-related 2 (herpesvirus entry mediator B)
References
  • Bachelet I, et al. (2006) Mast cell costimulation by CD226/CD112 (DNAM-1/Nectin-2): a novel interface in the allergic process. J Biol Chem. 281(37): 27190-6.
  • Wang L, et al. (2009) Molecular cloning, characterization and three-dimensional modeling of porcine nectin-2/CD112. Vet Immunol Immunopathol. 132(2-4): 257-63.

Standard Antibody Development Service

Rabbit MAb

Mouse MAb

Rabbit PAb

Fast Antibody Development Service

Mouse MAb

Rabbit PAb

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