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CD62L / L-Selectin / SELL 항체, 토끼 단클론항체

    데이터시트리뷰관련제품프로토콜
     SELL 항체 제품 정보
    면역원:Recombinant Mouse CD62L / L-Selectin / SELL Protein (Catalog#50045-M08H)
    Clone ID:023
    면역글로불린(Ig) 유형:Rabbit IgG
    농도:
    내독소:
    Formulation:0.2 μm filtered solution in PBS
    제조방법:This antibody was obtained from a rabbit immunized with purified, recombinant Mouse CD62L / L-Selectin / SELL (rM CD62L / L-Selectin / SELL; Catalog#50045-M08H; NP_035476.1; Met1-Asn332).
    Other SELL Antibody Products
    CD62L/L-Selectin 연구배경

    L-selectin (SELL), also known as CD62L, is a key adhesion molecule that regulates both the migration of leukocytes at sites of inflammation and the recirculation of lymphocytes between blood and lymphoid tissues. It belongs to the selectin family of proteins, and consisting of a large, highly glycosylated, extracellular domain, a single spanning transmembrane domain and a small cytoplasmic tail. L-selectin is the only selectin expressed on leukocytes and mediates a number of leukocyte-endothelial interactions. L-selectin acts as a "homing receptor" for leukocytes to enter secondary lymphoid tissues via high endothelial venules. Ligands present on endothelial cells will bind to leukocyte expressing L-selectin, slowing leukocyte trafficking through the blood, and facilitating entry into a secondary lymphoid organ at that point. L-selectin-mediated lymphocyte recirculation is required for maintaining the appropriate tissue distribution of lymphocyte subpopulations including naïve and effector subsets such as regulatory T cells. In addition, L-selectin-mediated entry into peripheral lymph nodes is required for optimal induction of lymphocyte homeostatic proliferation during lymphopenia. Importantly, L-selectin has been shown to have both adhesive and signaling functions during leukocyte migration. L-selectin has also been shown to mediate leukocyte recruitment during chronic inflammatory and autoimmune diseases and thus is a potential therapeutic target for drug development.

     CD62L/L-Selectin 참고자료
  • Smalley DM, et al. (2005) L-selectin: mechanisms and physiological significance of ectodomain cleavage. J Cell Mol Med. 9(2): 255-66.
  • Grailer JJ, et al. (2009) L-selectin: role in regulating homeostasis and cutaneous inflammation. J Dermatol Sci. 56(3): 141-7.
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    Cat No: 50045-R023-1
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    Datasheet & Documentation

    All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
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