Anti-Endoglin / CD105 Antibody

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Anti-Endoglin / CD105 Antibody (Rabbit Monoclonal antibody) General Information

Product name
Anti-Endoglin / CD105 Antibody
Validated applications
ELISA(Cap)
Species reactivity
Reacts with: Mouse
Specificity
Mouse Endoglin / CD105
Immunogen
Recombinant Mouse Endoglin / CD105 Protein (Catalog#50407-M08H)
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Mouse Endoglin / CD105 (rM Endoglin / CD105 ; Catalog#50407-M08H; NP_031958.2; Met1-Gly580).
Source
Monoclonal Rabbit IgG Clone #029
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-Endoglin / CD105 Antibody (Rabbit Monoclonal antibody) Validated Applications

Notes
ELISA(Cap): This antibody will detect Mouse Endoglin / CD105 in ELISA pair set (Catalog: # SEK50407). In a sandwich ELISA, it can be used as capture antibody when paired with (Catalog: # 50407-R028).
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-Endoglin / CD105 Antibody: Alternative Names

Anti-AI528660 Antibody; Anti-AI662476 Antibody; Anti-CD105 Antibody; Anti-Endo Antibody; Anti-S-endoglin Antibody

Endoglin / CD105 Background Information

Endoglin, also known as CD15, is a type I homodimeric transmembrane glycoprotein with a large, disulfide-linked, extracellular region and a short, constitutively phosphorylated cytoplasmic tail. Endoglin contains an RGD tripeptide which is a key recognition structure in cellular adhesion,,suggesting a critical role for endoglin in the binding of endothelial cells to integrins and/or other RGD receptors. Endoglin is highly expressed on vascular endothelial cells, chondrocytes, and syncytiotrophoblasts of term placenta. It is also found on activated monocytes, mesenchymal stem cells and leukemic cells of lymphoid and myeloid lineages. As an accessory receptor for the TGF-β superfamily ligands, endoglin binds TGF-β1 and TGF-β3 with high affinity not by itself but by associating with TGF-β type II receptor (TβRII) and activates the downstream signal pathways. In addition, in human umbilical vein endothelial cells, ALK-1 is also a receptor kinase for endoglin threonine phosphorylation, and mutations in either of the two genes result in the autosomal-dominant vascular dysplasia, hereditary hemorrhagic telangiectasia (HHT). Endoglin has been regarded as a powerful biomarker of neovascularization, and is associated with several solid tumor types.
Full Name
endoglin
References
  • Bellon T., et al.,(1993), Identification and expression of two forms of the human transforming growth factor-beta-binding protein endoglin with distinct cytoplasmic regions. Eur. J. Immunol. 23:2340-2345.
  • Humphray S.J., et al., (2004), DNA sequence and analysis of human chromosome 9.Nature 429:369-374.
  • Gougos A., et al.,(1990), Primary structure of endoglin, an RGD-containing glycoprotein of human endothelial cells.J. Biol. Chem. 265:8361-8364.
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