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염증성 사이토카인 및 케모카인

Sino Biological provides Inflammatory Cytokines and Chemokines for study of inflammatory, including recombinant proteins, antibodies (rabbit MAb, mouse MAb, rabbit PAb), ELISA kits, and gene cDNA clones.

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    염증성 사이토카인 및 케모카인 Background

    Inflammation is mediated by a variety of soluble factors, including a group of secreted polypeptides known as cytokines. Inflammatory cytokines can be divided into two groups: those involved in acute inflammation and those responsible. Inflammation, the response of tissue to injury, is characterized in the acute phase by increased blood flow and vascular permeability along with the accumulation of fluid, leukocytes, and inflammatory mediators such as cytokines. In the subacute / chronic phase (hereafter referred to as the chronic phase), it is characterized by the development of specific humoral and cellular immune responses to the pathogen (s) present at the site of tissue injury. During both acute and chronic inflammatory processes, a variety of soluble factors are involved in leukocyte recruitment through increased expression of cellular adhesion molecules and chemoattraction. Many of these soluble mediators regulate the activation of the resident cells (such as fibroblasts, endothelial cells, tissue macrophages, and mast cells) and the newly recruited inflammatory cells (such as monocytes, lymphocytes, neutrophils, and eosinophils), and some of these mediators result in the systemic responses to the inflammatory process. Several cytokines play key roles in mediating acute inflammatory reactions, namely IL-1, TNF-a, IL-6, IL-11, IL-8 and other chemokines, GCSF, and GM-CSF. The cytokines known to mediate chronic inflammatory processes can be divided into those participating in humoral inflammation, such as IL-3, IL-4, IL-5, IL-6, IL-7, IL-9, IL-10, IL-13, and transforming growth factor-b (TGF-b), and those contributing to cellular inflammation such as IL-1, IL-2, IL-3, IL-4, IL-7, IL-9, IL-10, IL-12, interferons (IFNs), IFN-g inducing factor (IGIF), TGF-b, and TNF-a and -b. Inflammatory abnormalities are a large group of disorders which underlie a vast variety of human diseases. The immune system is often involved with inflammatory disorders, demonstrated in both allergic reactions and some myopathies, with many immune system disorders resulting in abnormal inflammation.

    염증성 사이토카인 및 케모카인 References

    1. Carol A, et al. (1997) Cytokines in acute and chronic inflammation. Frontiers in Bioscience 2:12-26.
    2. Dent AL, et al. (1997) Control of inflammation, cytokine expression, and germinal center formation by BCL-6. Science. 276(5312): 589-92.
    3. Lin WW, et al. (2007) A cytokine-mediated link between innate immunity, inflammation, and cancer. J Clin Invest. 117(5): 1175-83.