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    Leukemia Inhibitory Factor/LIF 관련 제품

    Leukemia Inhibitory Factor/LIF 관련 제품

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    Leukemia Inhibitory Factor/LIF 요약 및 단백질 정보

    Leukemia Inhibitory Factor/LIF 관련 정보

    Leukemia Inhibitory Factor/LIF 배경

    유전자 요약: The protein encoded by this gene is a pleiotropic cytokine with roles in several different systems. It is involved in the induction of hematopoietic differentiation in normal and myeloid leukemia cells, induction of neuronal cell differentiation, regulator of mesenchymal to epithelial conversion during kidney development, and may also have a role in immune tolerance at the maternal-fetal interface. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
    General information above from NCBI
    세포하 위치: Secreted.
    염기서열 유사성: Belongs to the LIF/OSM family. {ECO:0000305}.
    General information above from UniProt

    Leukemia inhibitory factor (LIF) is a pleiotropic glycoprotein belonging to the IL-6 family of cytokines. It’s involved in growth promotion and cell differentiation of different types of target cells, influence on bone metabolism, cachexia, neural development, embryogenesis and inflammation. LIF has potent proinflammatory property, being the inducer of the acute phase protein synthesis and affecting the cell recruitment into the area of damage or inflammation. LIF is also one of the cytokines that are capable to regulate the differentiation of embryonic stem cells, hematopoietic and neuronal cells. LIF binds to the specific LIF receptor (LIFR-α) which forms a heterodimer with a specific subunit common to all members of that family of receptors, the GP130 signal transducing subunit. This leads to activation of the JAK/STAT and MAPK cascades. Due to its polyfunctional activities, LIF is involved in the pathogenic events and development of many diseases of various origin.

    Leukemia Inhibitory Factor/LIF 대체 이름

    Leukemia Inhibitory Factor,CDF,DIA,HILDA,MLPLI, []
    CDF,DIA,HILDA,MLPLI, [homo-sapiens]
    d factor,OTTMUSP00000005253,RP23-329P17.1, [human]

    Leukemia Inhibitory Factor/LIF 관련 연구

  • Salas EM, et al. (2011) LIF, a Novel STAT5-Regulated Gene, Is Aberrantly Expressed in Myeloproliferative Neoplasms. Genes Cancer. 2 (5): 593-6.
  • Chodorowska G, et al. (2004) Leukemia inhibitory factor (LIF) and its biological activity. Ann Univ Mariae Curie Sklodowska Med. 59 (2): 189-93.
  • Garcia-Campana AM, et al. (2007) LIF detection of peptides and proteins in CE. Electrophoresis. 28 (1-2): 208-32.
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