Neurotrophin 3 Protein, Human, Recombinant

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Neurotrophin 3 Protein, Human, Recombinant: Product Information

Purity
> 90 % as determined by SDS-PAGE
Endotoxin
Please contact us for more information.
Activity
Measured by its binding ability in a functional ELISA.
Immobilized human NT3 at 10 μg/ml (100 μl/well) can bind human TrkB-Fch (Cat:10047-H03H). The EC50 of human TrkB-Fch (Cat:10047-H03H) is 28.2-65.8 ng/mL.
Protein Construction
A DNA sequence encoding the human NT3 (P20783-1) (Tyr139-Thr257) was expressed and purified.
Accession#
Expressed Host
E. coli
Species
Human
Predicted N Terminal
Met
Molecule Mass
The recombinant human NT3 consists of 120 amino acids and has a predicted molecular mass of 13.8 kDa. The apparent molecular mass of it is approximately 16 kDa in SDS-PAGE under reducing conditions.
Formulation
Lyophilized from sterile PBS, pH 5.2.
Please contact us for any concerns or special requirements.
Please refer to the specific buffer information in the hard copy of CoA.
Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Stability & Storage
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃
Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Neurotrophin 3 Protein, Human, Recombinant: Images

Neurotrophin 3 Protein, Human, Recombinant: Alternative Names

HDNF Protein, Human; NGF-2 Protein, Human; NGF2 Protein, Human; NT-3 Protein, Human; NT3 Protein, Human

Neurotrophin 3 Background Information

Neurotrophin-3 (NTF3) is a key mediator of neuronal development during the early neurogenic period, as a putative regulatory target of POU3F2. NTF3 is a novel target gene of POU3F2 and that the POU3F2/NTF3 pathway plays a role in the process of neuronal differentiation. Neurotrophin 3 (NTF3) is capable of activating TrkB to induce anoikis resistance, and show that NTF3 is also a direct target of miR-2c.
Full Name
neurotrophin 3
  • BDNF/NT3 Regulate AIS Location and Affect Neuronal Excitability in Cultured Hippocampal Neurons
    Author
    Guo, Y;Su, ZJ;Chen, YK;Chai, Z;
    Year
    2017
    Journal
    J. Neurochem.
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