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Neurotrophin & Receptor

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    뉴로트로핀 및 수용체 Background

    Neurotrophin & Receptor
    Neurotrophin family Neurotrophin function
    Neurotrophin Receptors Neurotrophin pathway / signaling
    NGF (Nerve Growth Factor )
    NGF molecular weight NGF structure NGF function
    NGF signaling / pathway NGF receptor NGF TrkA & NGFR / p75
    BDNF (Brain-derived neurotrophic factor )
    BDNF Gene BDNF function BDNF signaling / pathway
    BDNF receptor BDNF TrkB NGFR / p75
    Other Neurotrophin & Receptor
    Neurotrophin-3 / NT-3 TrkA / NTRK1 TrkB / NTRK2
    TrkC / NTRK3 NGFR (p75 / p75 NTR)  
    GDNF (Glial cell line-derived neurotrophin) Family
    GFRA3 NCAM / CD56  
    Other Neurotrophic Factors & Receptors
    MANF / ARMET Gp130 / IL6ST LIFR / CD118
    CNTF / Ciliary Neurotrophic Factor CDNF / ARMETL1 NRG1 / Neuregulin 1
    NRG4 / Neuregulin 4 Pleiotrophin / PTN CNTFR
    Growth Factor Family
    Angiopoietin/Tie Ephrin & Eph Receptor EGF & Receptor
    FGF & Receptor Insulin-like Growth Factor System PDGF & Receptor
    Receptor Tyrosine Kinase R-Spondin Protein VEGF & Receptor
    Wnt Ligands & Receptors    

    Neurotrophins are a family of growth factors that are capable of stimulating the survival, development and function of neurons. Neurotrophins act by preventing the associated neuron from initiating programmed cell death, and thus allowing the neurons to survive. Neurotrophins also help to stimulate and control neurogenesis, a process that new neurons develop from neural stem cells. The term “Neurotrophin” refers to four structurally related neurotrophic factors: nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and neurotrophin-4 (NT-4). Novel neurotrophin-1 (NNT1) is another neurotrophic factor, but it is structurally unrelated to NGF, BDNF, NT-3 and NT-4. Neurotrophins act through two classes of receptors: p75 and the Trk family of receptor tyrosine kinases (TrkA, TrkB and TrkC). Each neurotrophin has been shown to activate one or more of the three Trks. p75 neurotrophin receptor (p75NTR), a member of the tumour necrosis factor receptor superfamily, is also activated by each neurotrophin. Neurotrophins stimulate signaling pathways controlled through Ras, phosphatidyl inositol-3 (PI3)-kinase and phospholipase C-gamma1. Neurotrophins control the survival and development of neurons. Neurotrophins also play important roles in regulating axon growth, dendrite cell growth and pruning and the expression of proteins. Aberrant control of neurotrophins and their receptors lead to many diseases. For example, the neurotrophin receptor p75 is related to Alzheimer’s disease.

    뉴로트로핀 및 수용체 References

      1. Pitts EV, et al. (2006) Neurotrophin and Trk-mediated signaling in the neuromuscular system. Int Anesthesiol Clin. 44(2):21-76.
      2. Chao MV, et al. (2006) Neurotrophin signalling in health and disease. Clin Sci (Lond). 110(2):167-73.
      3. Reichardt LF. (2006) Neurotrophin-regulated signalling pathways. Philos Trans R Soc Lond B Biol Sci. 361(1473):1545-64.
      4. Diarra A, et al. (2009) Signaling of the neurotrophin receptor p75 in relation to Alzheimer's disease. Biochem Biophys Res Commun. 390(3):352-6.