Anti-SOX2 Antibody

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Anti-SOX2 Antibody (Rabbit Monoclonal antibody) General Information

Product name
Anti-SOX2 Antibody
Validated applications
WB
Species reactivity
Reacts with: Human
Specificity
Human SOX2
Immunogen
A synthetic peptide corresponding to the N-terminus of the human Sox2.
Preparation
This antibody was obtained from a rabbit immunized with a synthetic peptide corresponding to the N-terminus of the human Sox2.
Source
Monoclonal Rabbit IgG Clone #018
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-SOX2 Antibody (Rabbit Monoclonal antibody) Validated Applications

Application Dilution
WB 1:500-1:2000
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-SOX2 Antibody (Rabbit Monoclonal antibody) Images

Anti-Sox2 rabbit monoclonal antibody at 1:500 dilution

Lane A: HESS9 Whole Cell Lysate

Lysates/proteins at 30 μg per lane.

Secondary

Goat Anti-Rabbit IgG H&L (Dylight800) at 1/10000 dilution.

Developed using the Odyssey technique.

Performed under reducing conditions.

Predicted band size:34 kDa

Observed band size:37 kDa

Anti-SOX2 Antibody: Alternative Names

Anti-ANOP3 Antibody; Anti-MCOPS3 Antibody

SOX2 Background Information

SOX2, also known as ANOP3, is a transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP26. SOX2 is critical for early embryogenesis and for embryonic stem cell pluripotency. It keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation. Defects in SOX2 can cause microphthalmia, syndromic, 3. A disease characterized by the rare association of malformations including uni- or bilateral anophthalmia or microphthalmia, and esophageal atresia with trachoesophageal fistula.
Full Name
SRY (sex determining region Y)-box 2
References
  • Lu Y, et al., 2010, PLoS ONE. 5(6): e11022.
  • Gontan C, et al., 2008, Dev. Biol. 317 (1): 296-309.
  • Shi W, et al., 2006, J. Biol. Chem. 281 (33): 23319-25.
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