TL1A (Protein | Antibody | cDNA Clone | ELISA Kit)

All TL1A reagents are produced in house and quality controlled, including 29 TL1A Gene, 4 TL1A Lysate, 4 TL1A Protein, 1 TL1A qPCR. All TL1A reagents are ready to use.

TL1A Protein (4)

    TL1A cDNA Clone (29)

    NM_005118.3
    NM_177371.3

    In cloning vector

    In lentiviral vector

    NM_145765.1
    XM_005580961.1

    In cloning vector

    TL1A qPCR Primer (1)

    TL1A Lysate (4)

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      TL1A Background

      TL1A, also known as TNFSF15, is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. It is specifically expressed in endothelial cells. TL1A also can be detected in monocytes, placenta, lung, liver, kidney, skeletal muscle, pancreas, spleen, prostate, small intestine and colon. TL1A is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It mediates activation of NF-kappa-B. It also inhibits vascular endothelial growth and angiogenesis (in vitro). TL1A promotes activation of caspases and apoptosis. It is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor.

      TL1A References

      • Jin T, et al. (2007) X-ray crystal structure of TNF ligand family member TL1A at 2.1A. Biochem Biophys Res Commun. 364(1):1-6.
      • Cassatella MA, et al. (2007) Soluble TNF-like cytokine (TL1A) production by immune complexes stimulated monocytes in rheumatoid arthritis. J Immunol. 178(11):7325-33
      • Prehn JL, et al. (2007) The T cell costimulator TL1A is induced by FcgammaR signaling in human monocytes and dendritic cells. J Immunol. 178(7):4033-8.