Allergic Disease Drug Targets in Cytokines & Growth Factors

Production of IgE antibodies promotes the development of allergic diseases such as asthma, rhinitis and atopic eczema. Production of IgE ab is dependent upon the Th2 cytokine. So Th2 cytokines play a pivotal role in the allergic disease cascade and some cytokines may serve as pivotal drug targets in allergic disease therapy.
Here the main autoimmune disease drug targets were listed included in cytokines and growth factors. And quality reagents to facilitate your research are available here.

Cytokine drug targets for:

Vital Allergic Disease Drug Targets in Cytokines & Growth Factors

IL-5

The notion that IL-5-regulated eosinophilia plays a central role in the pathogenesis of asthma is based on extensive circumstantial evidence. The eosinophil paradigm identifies IL-5-regulated eosinophilia as a central pathogenic pathway of asthma. This led to the development therapeutic antibody.

IL-4

Interleukin-4 (IL-4) mediates important pro-inflammatory functions in asthma including induction of the IgE isotype switch, expression of vascular cell adhesion molecule-1 (VCAM-1), promotion of eosinophil transmigration across endothelium, mucus secretion, and differentiation of T helper type 2 lymphocytes leading to cytokine release.

IL-1β

The findings support a crucial role for IL-1β and inflammasome components in a variety of allergy related disorders. IL-1-neutralizing drugs have been shown to completely suppress or markedly reduce inflammatory responses in clinical studies and experimental models common allergic disorders.

IL-9

Cell biology in vitro has shown that IL-9 is an important growth factor and stimulator of numerous cell types important in the pathogenesis of asthma. Mice overexpressing IL-9 and neutralizing antibodies further demonstrate a crucial role for IL-9 in the development of the allergic asthmatic response.

Allergic Disease Drug Targets List in Cytokines & Growth Factors

Allergic Disease Drug Targets in Cytokines & Growth Factors Reference

• Woodfolk J A. Cytokines as a therapeutic target for allergic diseases: a complex picture[J]. Current pharmaceutical design, 2006, 12(19): 2349-2363.
• Foster P S, et al. Interleukin-5 and eosinophils as therapeutic targets for asthma[J]. Trends in molecular medicine, 2002, 8(4): 162-167.
• Steinke JW, et al. Th2 cytokines and asthma — Interleukin-4: its role in the pathogenesis of asthma, and targeting it for asthma treatment with interleukin-4 receptor antagonists. Respiratory Research. 2001;2(2):66-70.
• Zhou Y, et al. Th2 cytokines and asthma—Interleukin-9 as a therapeutic target for asthma[J]. Respiratory research, 2001, 2(2): 80.