MERS-CoV (NCoV / Novel coronavirus) Nucleocapsid Protein Antibody, Rabbit PAb, Antigen Affinity Purified

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MERS-CoV (NCoV / Novel coronavirus) Nucleocapsid Protein Antibody, Rabbit PAb, Antigen Affinity Purified (Rabbit Polyclonal antibody) General Information

Product name
MERS-CoV (NCoV / Novel coronavirus) Nucleocapsid Protein Antibody, Rabbit PAb, Antigen Affinity Purified
Validated applications
WB,IHC-P,ICC/IF,IP (Antibody's applications have not been validated with corresponding viruses. Optimal concentrations/dilutions should be determined by the end user.)
Application notes
(Antibody's applications have not been validated with corresponding viruses. Optimal concentrations/dilutions should be determined by the end user.)
Specificity
MERS-CoV CoV Nucleoprotein
Immunogen
A synthetic peptide corresponding to the center region of MERS-CoV (NCoV / Novel coronavirus) Nucleocapsid Protein (NP protein).
Preparation
Produced in rabbits immunized with purified, a synthetic peptide corresponding to the center region of MERS-CoV (NCoV / Novel coronavirus) Nucleocapsid Protein (NP protein), and purified by antigen affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

MERS-CoV (NCoV / Novel coronavirus) Nucleocapsid Protein Antibody, Rabbit PAb, Antigen Affinity Purified (Rabbit Polyclonal antibody) Validated Applications

Application Dilution
WB 1:1000-1:5000
Please Note: Optimal concentrations/dilutions should be determined by the end user.

MERS-CoV (NCoV / Novel coronavirus) Nucleocapsid Protein Antibody, Rabbit PAb, Antigen Affinity Purified (Rabbit Polyclonal antibody) Images

Anti-Novel coronavirus (HCoV-EMC/2012) Nucleoprotein / NP rabbit polyclonal antibody at 1:1000 dilition.

Sample:Novel coronavirus (HCoV-EMC/2012) Nucleoprotein / NP

Lane A: 500ng

Lane B: 200ng

Lane C: 100ng

Secondary

Goat Anti- Rabbit IgG (H+L)/HRP at 0.4ug/ml dilution.

Performed under reducing conditions.

MERS-CoV (NCoV / Novel coronavirus) Nucleocapsid Protein Antibody, Rabbit PAb, Antigen Affinity Purified: Alternative Names

Anti-NP Antibody

CoV Nucleoprotein Background Information

Coronaviruses are enveloped viruses with a positive-sense RNA genome and with a nucleocapsid of helical symmetry. Coronaviruses primarily cause respiratory and enteric diseases in mammals and birds. Coronaviruses can cause a range of symptoms varying from mild symptoms such as the common cold to more serious respiratory illnesses. They primarily cause respiratory and enteric diseases in mammals and birds. Coronavirus symptoms include rhinorrhea, sneezing, cough, nasal obstruction, bronchitis and so on. There are three main groups of coronaviruses: alpha, beta, and gamma. Proteins that contribute to the overall structure of all coronaviruses are the spike (S), envelope (E), membrane (M) and nucleoprotein (N). Coronavirus nucleoproteins localize to the cytoplasm and the nucleolus, a subnuclear structure, in both virus-infected primary cells and in cells transfected with plasmids that express N protein. Coronavirus N protein is required for coronavirus RNA synthesis, and has RNA chaperone activity that may be involved in template switch.
References
    1. 1.Van Boheemen S, et al. (2012), MBio. 3(6):e00473-12.
    2. Bisht H. et al., 2004, Proc Natl Acad Sci. 101 (17): 6641-6.
    3. Li W. et al., 2005, Science. 309 (5742): 1864-8.
  • Recombinant Receptor Binding Domain Protein Induces Partial Protective Immunity in Rhesus Macaques Against Middle East Respiratory Syndrome Coronavirus Challenge
    Author
    Lan, J;Yao, Y;Deng, Y;Chen, H;Lu, G;Wang, W;Bao, L;
    Year
    2015
    Journal
    EBioMedicine
    Application
    IHC
  • Recombinant Receptor Binding Domain Protein Induces Partial Protective Immunity in Rhesus Macaques Against Middle East Respiratory Syndrome Coronavirus Challenge
    Author
    Lan, J;Yao, Y;Deng, Y;Chen, H;Lu, G;Wang, W;Bao, L;
    Year
    2015
    Journal
    EBioMedicine
    Application
    IHC
  • The recombinant N-terminal domain of spike proteins is a potential vaccine against Middle East respiratory syndrome coronavirus (MERS-CoV) infection
    Author
    Jiaming, L;Yanfeng, Y;Yao, D;Yawei, H;Linlin, B;Baoying, H;Jinghua, Y;Gao, GF;Chuan, Q;Wenjie, T;
    Year
    2017
    Journal
    Vaccine
    Application
    IHC
  • Enhanced protection in mice induced by immunization with inactivated whole viruses compare to spike protein of middle east respiratory syndrome coronavirus
    Author
    Deng, Y;Lan, J;Bao, L;Huang, B;Ye, F;Chen, Y;Yao, Y;Wang, W;Qin, C;Tan, W;
    Year
    2018
    Journal
    Emerg Microbes Infect
    Application
    IHC

Standard Antibody Development Service

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Rabbit PAb

Fast Antibody Development Service

Mouse MAb

Rabbit PAb

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