Anti-Androgen receptor Antibody, Rabbit Polyclonal

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Anti-Androgen receptor Antibody, Rabbit Polyclonal (Rabbit Polyclonal antibody) General Information

Product name
Anti-Androgen receptor Antibody, Rabbit Polyclonal
Validated applications
WB
Species reactivity
Reacts with: Human
Specificity
Human Androgen receptor
Immunogen
A synthetic peptide corresponding to the N-terminus of the Human Androgen receptor / AR
Preparation
Produced in rabbits immunized with a synthetic peptide corresponding to the N-terminus of the Human Androgen receptor / AR, and purified by antigen affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-Androgen receptor Antibody, Rabbit Polyclonal (Rabbit Polyclonal antibody) Validated Applications

Application Dilution
WB 1:500-1:2000
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-Androgen receptor Antibody, Rabbit Polyclonal (Rabbit Polyclonal antibody) Images

Anti-Androgen receptor rabbit polyclonal antibody at 1:500 dilution

Lane A: HepG2 Whole Cell Lysate

Lane B: Hela Whole Cell Lysate

Lane C: 293T Whole Cell Lysate

Lysates/proteins at 30 μg per lane.

Secondary

Goat Anti-Rabbit IgG H&L (Dylight800) at 1/10000 dilution.

Developed using the Odyssey technique.

Performed under reducing conditions.

Predicted band size:98 kDa

Observed band size:100 kDa

(We are unsure as to the identity of these extra bands.)

Anti-Androgen receptor Antibody, Rabbit Polyclonal: Synonyms

Anti-AIS Antibody; Anti-DHTR Antibody; Anti-HUMARA Antibody; Anti-HYSP1 Antibody; Anti-KD Antibody; Anti-NR3C4 Antibody; Anti-SBMA Antibody; Anti-SMAX1 Antibody; Anti-TFM Antibody

Androgen receptor Background Information

The androgen receptor gene is more than 9 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract from the normal 9-34 repeats to the pathogenic 38-62 repeats causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described.
Full Name
androgen receptor
Research Areas
References
  • Fajardo AM, MacKenzie DA, Olguin SL, Scariano JK, Rabinowitz I, Thompson TA. Antioxidants Abrogate Alpha-Tocopherylquinone-Mediated Down-Regulation of the Androgen Receptor in Androgen-Responsive Prostate Cancer Cells. Languino LR, ed. PLoS ONE. 2016;11(3):e0151525.

Standard Antibody Development Service

Rabbit MAb

Mouse MAb

Rabbit PAb

Fast Antibody Development Service

Mouse MAb

Rabbit PAb

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