Anti-beta-III Tubulin/TUBB3 Antibody, Mouse Monoclonal

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Anti-beta-III Tubulin/TUBB3 Antibody, Mouse Monoclonal (Mouse Monoclonal antibody) General Information

Product name
Anti-beta-III Tubulin/TUBB3 Antibody, Mouse Monoclonal
Validated applications
WB
Species reactivity
Reacts with: Human
Specificity
Human beta-III Tubulin/TUBB3
Immunogen
A synthetic peptide corresponding to the N-terminus of the human TUBB3.
Preparation
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with a synthetic peptide corresponding to the N-terminus of the human TUBB3. The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
Source
Monoclonal Mouse IgG1 Clone #01
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-beta-III Tubulin/TUBB3 Antibody, Mouse Monoclonal (Mouse Monoclonal antibody) Validated Applications

Application Dilution
WB 1:500-1:2000
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-beta-III Tubulin/TUBB3 Antibody, Mouse Monoclonal (Mouse Monoclonal antibody) Images

Anti-HistoneH2A mouse monoclonal antibody at 1:500 dilution

Lane A: Hela Whole Cell Lysate

Lane B: K562 Whole Cell Lysate

Lysates/proteins at 30 μg per lane.

Secondary

Goat Anti-Mouse IgG H&L (Dylight800) at 1/15000 dilution.

Developed using the Odyssey technique.

Performed under reducing conditions.

Predicted band size:14 kDa

Observed band size:14 kDa

Anti-beta-III Tubulin/TUBB3 Antibody, Mouse Monoclonal: Synonyms

Anti-beta-4 Antibody; Anti-CDCBM Antibody; Anti-CDCBM1 Antibody; Anti-CFEOM3 Antibody; Anti-CFEOM3A Antibody; Anti-FEOM3 Antibody; Anti-TUBB4 Antibody

beta-III Tubulin/TUBB3 Background Information

The overexpression of TUBB3 could be related to reduced efficiency of taxane-based targeting anticancer drugs in several cancer types. TUBB3 serves as an independent prognostic marker and may be a valuable biomarker for routine application in esophageal adenocarcinoma especially to address the need for adjuvant treatment in individuals following neoadjuvant therapy and surgery. TUBB3 is of clinical relevance as overexpression has been linked to poor response to microtubule-targeting anti-cancer drugs such as taxanes. Mutations in TUBB3 have been associated with complex cortical dysplasia and other brain malformations and congenital fibrosis of extraocular muscles type 3A (CFEOM3A). The direct silencing of TUBB3 reverses induced multiple cross-resistance, reduces drug-resistant tumor mass, and suppresses the impaired microtubule stability status of PTX-resistant cells with transient cross-resistance.
Full Name
tubulin, beta 3 class III

Standard Antibody Development Service

Rabbit MAb

Mouse MAb

Rabbit PAb

Fast Antibody Development Service

Mouse MAb

Rabbit PAb

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