Recombinant Anti-BMI1 Antibody, Rabbit Monoclonal

EliteRmab®, manufactured by recombinant technology
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Recombinant Anti-BMI1 Antibody, Rabbit Monoclonal (Rabbit Monoclonal antibody) General Information

Product name
Recombinant Anti-BMI1 Antibody, Rabbit Monoclonal
Validated applications
IHC-P
Species reactivity
Reacts with: Human
Predicted to React with: Mouse (Species predicted to react based on 100% sequence homology)
Specificity
Human BMI1
Immunogen
A synthetic peptide corresponding to the center region of the Human BMI1
Preparation
This antibody was obtained from a rabbit immunized with a synthetic peptide corresponding to the center region of the Human BMI1. The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
Source
Monoclonal Rabbit IgG Clone #116
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Recombinant Anti-BMI1 Antibody, Rabbit Monoclonal (Rabbit Monoclonal antibody) Validated Applications

Application Dilution
IHC-P 1:100-1:500
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Recombinant Anti-BMI1 Antibody, Rabbit Monoclonal (Rabbit Monoclonal antibody) Images

Immunochemical staining of human BMI1 in human skeletal muscle with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections).

Recombinant Anti-BMI1 Antibody, Rabbit Monoclonal: Synonyms

Anti-FLVI2/BMI1 Antibody; Anti-PCGF4 Antibody; Anti-RNF51 Antibody

BMI1 Background Information

Polycomb group member protein BMI1 is involved in maintaining cell identity, proliferation, differentiation and human oncogenesis. BMI1 mRNA expression in whole blood might represent a new biomarker for the diagnosis and prognosis of NSCLC. In human myoblasts, BMI1 overexpression increases mitochondrial activity, leading to an enhanced energetic state with increased ATP production and concomitant protection against DNA damage both in vitro and upon xenografting in a severe dystrophic mouse model. BMI1 inhibition suppressed proliferation of leukemia cells through NOTCH signaling which functions downstream of BMI1, suggesting that BMI1 inhibitors can be candidate targeted drugs against leukemia. BMI1 decreases ATR activation through a mechanism that involves binding to TOPBP1 and/or ATR. BMI1 over-expression may be useful in identifying patients who might benefit from novel therapies directed at reversing the chromatin-modifying functions of BMI1.
Full Name
BMI1 proto-oncogene, polycomb ring finger

Standard Antibody Development Service

Rabbit MAb

Mouse MAb

Rabbit PAb

Fast Antibody Development Service

Mouse MAb

Rabbit PAb

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