Recombinant Anti-BMI1 Antibody, Rabbit Monoclonal (Rabbit Monoclonal antibody) General Information
Recombinant Anti-BMI1 Antibody, Rabbit Monoclonal
Reacts with: Human Predicted to React with:
Mouse (Species predicted to react based on 100% sequence homology)
A synthetic peptide corresponding to the center region of the Human BMI1
This antibody was obtained from a rabbit immunized with a synthetic peptide corresponding to the center region of the Human BMI1. The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
Monoclonal Rabbit IgG Clone #116
0.2 μm filtered solution in PBS
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.
Polycomb group member protein BMI1 is involved in maintaining cell identity, proliferation, differentiation and human oncogenesis. BMI1 mRNA expression in whole blood might represent a new biomarker for the diagnosis and prognosis of NSCLC. In human myoblasts, BMI1 overexpression increases mitochondrial activity, leading to an enhanced energetic state with increased ATP production and concomitant protection against DNA damage both in vitro and upon xenografting in a severe dystrophic mouse model. BMI1 inhibition suppressed proliferation of leukemia cells through NOTCH signaling which functions downstream of BMI1, suggesting that BMI1 inhibitors can be candidate targeted drugs against leukemia. BMI1 decreases ATR activation through a mechanism that involves binding to TOPBP1 and/or ATR. BMI1 over-expression may be useful in identifying patients who might benefit from novel therapies directed at reversing the chromatin-modifying functions of BMI1.
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